Pharmacological modulation of cell functional activity with valproic acid and erythropoietin
| Autor: | Marina V. Sarycheva, Yuriy E. Burda, Natalya A. Nadezhdina, Maksim V. Puzanov, Svetlana Y. Burda, Vladimir F. Kulikovskiy, S. V. Nadezhdin, Michail V. Korokin, Polina A. Golubinskaya |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
genetic structures Cell RM1-950 Pharmacology behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine valproic acid medicine Pharmacology (medical) Pharmacological modulation mesenchymal stem cells Valproic Acid Chemistry 030104 developmental biology medicine.anatomical_structure nervous system Erythropoietin cell technologies Functional activity lipids (amino acids peptides and proteins) biomedical cellular products Therapeutics. Pharmacology erythropoietin psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Research Results in Pharmacology, Vol 5, Iss 2, Pp 89-99 (2019) |
| ISSN: | 2658-381X |
| DOI: | 10.3897/rrpharmacology.5.34710 |
| Popis: | Introduction: Valproic acid (VA) is carboxylic acid with a branched chain, which is used as an antiepileptic drug. Valproic acid influence on cells in vivo: VA, which is an antiepileptic drug, is also a teratogen, which causes defects of a neural tube and an axial skeleton, although the mechanisms are not yet fully clear. Valproic acid influence on mesenchymal stem cells (MSC) in vitro: It is shown that valproic acid reduces the intracellular level of oxygen active forms. Valproic acid effect on tumor cells: VA inhibits tumor growth through several mechanisms, including the cell cycle stop, differentiation induction and inhibition of growth of tumor vessels. Valproic acid influence on enzymes: It affects mainly GSK-3. Valproic acid influence on animals’ cells: It is shown that VA can significantly improve an ability to develop in vitro and improve nuclear reprogramming of embryos. Erythropoietin (EPO): Is an hypoxia-induced hormone and a cytokine, which is necessary for normal erythropoiesis. EPO is widely used in in vitro experiments. Conclusion: Thus, the influence of VA and EPO on cells can be used in cell technologies. |
| Databáze: | OpenAIRE |
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