Orthotopic liver transplantation, Epstein-Barr virus, cyclosporine, and lymphoproliferative disease: a growing concern
| Autor: | Basil J. Zitelli, Andrew H. Urbach, J. Carlton Gartner, J. Jeffrey Malatack |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Herpesvirus 4 Human Orthotopic liver transplantation Bone marrow transplantation Cyclosporins medicine.disease_cause Gastroenterology Postoperative Complications Risk Factors hemic and lymphatic diseases Internal medicine medicine Humans Child business.industry Infant Effective management Herpesviridae Infections Epstein–Barr virus Lymphoproliferative Disorders Surgery Liver Transplantation Child Preschool Pediatrics Perinatology and Child Health Lymphoproliferative disease business Complication |
| Zdroj: | The Journal of pediatrics. 118(5) |
| ISSN: | 0022-3476 |
| Popis: | Lymphoproliferative disease (LPD) is a well-recognized complication of both solid organ and bone marrow transplantations. The occurrence of LPD in these settings is related in part to the use of the immunosuppressive agent cyclosporine. We report 12 cases of LPD after orthotopic liver transplantations in 132 pediatric patients. Lymphoproliferative disease occurred as one of three clinical syndromes: (1) lymphadenopathic, (2) systemic, and (3) lymphomatous. Effective management of LPD with excisional therapy or reduction of immunosuppressive medications or both resulted in the survival of 7 of 12 patients. In an alarming and increasing percentage of patients after orthotopic liver transplantation, progressive LPD develops with lethal outcome (5/12 patients). Early recognition of LPD and aggressive intervention may improve outcome in this group. |
| Databáze: | OpenAIRE |
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