Lipoprotein profile assessed by 2D-1H-NMR and subclinical atherosclerosis in children with familial hypercholesterolaemia

Autor: De Gotardo Enrique, Luque Verónica, Fernández Marta, Doménech Vanesa, Cèlia Rodríguez-Borjabad, García Joan, Monne Raquel, Girona Raquel, Escolà Maria, Aguado Fèlix, Josefa Girona, Bilbao José Ángel, Núria Plana, Calvo Josefa, Cliville Rosa, Zalaba Eduardo, Cabedo José Luís, Gutiérrez Ma Antonia, Segura Sandra, Vendrell Montserrat, Salvador Olga, Mallafré Marta, Rabadà Ma José, Amigó Elisabeth, Santos Alicia, Morillo Susana, Iglesias Dolores, Barrio Mercedes, Domínguez Dolores, Martin Ramona, Machado Pilar, Núria Amigó, Eugenio Guijarro, Planelles Montserrat, Castejón Emma, Vilella Mireia, Jaume Miquel Salsas, Duràn-Ballén Marta, Campillo Carmen, Sanz Núria, Luis Masana, Pérez Cristina, Riquelme Carmen, Daiana Ibarretxe, Milagros Jiménez, Subirana Gloria, A. Feliu, Castro María, Querol Cecilia, Remedi Ayelen, Naranjo Àngels, Tarrades Pilar, Rodríguez Neus, Maixé Jordi, Andrés Patricia, Rosell Laura, Raimon Ferré, Castillejo Gemma, Bosch Montserrat, Salvado Maria
Rok vydání: 2017
Předmět:
Carotid Artery Diseases
Male
medicine.medical_specialty
Multivariate analysis
Adolescent
Proton Magnetic Resonance Spectroscopy
030204 cardiovascular system & hematology
Lipoprotein particle
Gastroenterology
Carotid Intima-Media Thickness
Hyperlipoproteinemia Type II
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
Plasma lipids
Medicine
Humans
Medical history
Genetic Predisposition to Disease
030212 general & internal medicine
Age of Onset
Particle Size
Child
business.industry
Cholesterol
Anthropometry
Lipoproteins
LDL
Cross-Sectional Studies
Phenotype
chemistry
Spain
Subclinical atherosclerosis
Case-Control Studies
Child
Preschool
Asymptomatic Diseases
lipids (amino acids
peptides
and proteins)
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Lipoprotein
Zdroj: Atherosclerosis. 270
ISSN: 1879-1484
Popis: Background and aims Familial hypercholesterolaemia (FH) is underdiagnosed in children. In addition to lipid concentrations, lipoprotein particle quantity and quality could influence cardiovascular risk. We aimed to perform a comprehensive plasma lipid study, including lipoprotein particle number and size assessment by two-dimensional nuclear magnetic resonance (2D-1H-NMR), in children with FH compared to non-affected children and to evaluate the clinical value of these factors as subclinical atherosclerosis biomarkers. Methods One hundred eighty-three children participating in the broad “Hypercholesterolemia Early Detection Programme” (Decopin Project) were recruited. They were categorized as FH, if they had either a positive genetic test or clinical certainty, or as control children (CCh). Medical history, anthropometry and clinical variables were recorded. Standard biochemical measurements were performed. The lipoprotein profile was studied by 2D-1H-NMR. Carotid intima-media thickness (cIMT) was assessed by sonography in 177 children. Results FH children had a significant 36% increase in LDL particles. The small LDL fraction was increased by 33% compared to CCh. The relative relationship between large, medium and small LDL and the mean LDL particle size was similar between FH children and CCh. The total and small LDL particle numbers were directly associated with and contributed to the determination of the mean cIMT according to bivariate and multivariate analyses in FH children. Conclusions The higher cholesterol levels of FH children are due to an overall increased number of all LDL particle subclasses, including a notable 33% increase in small LDL. Total and small LDL particle number shows a good correlation with cIMT in FH children.
Databáze: OpenAIRE
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