Carboxyl-terminal tripeptide of alpha-melanocyte-stimulating hormone antagonizes interleukin-1-induced anorexia
| Autor: | Uehara Yutaka, Mori Masatomo, Sato Noriyuki, Tanaka Yoshito, Shimomura Yohnosuke, Shimizu Hiroyuki |
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| Rok vydání: | 1992 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Melanocyte-stimulating hormone Molecular Sequence Data Anorexia Tripeptide Peptide hormone Biology Internal medicine medicine Animals Amino Acid Sequence Rats Wistar Interleukin 5 Injections Intraventricular Pharmacology Binding Sites integumentary system digestive oral and skin physiology Interleukin Feeding Behavior Peptide Fragments Rats Endocrinology Mechanism of action alpha-MSH medicine.symptom hormones hormone substitutes and hormone antagonists Hormone Interleukin-1 |
| Zdroj: | European journal of pharmacology. 220(2-3) |
| ISSN: | 0014-2999 |
| Popis: | Interleukin-1 beta (IL-1), a cytokine released from inflammatory cells, is thought to be involved in the anorexia associated with severe infection. To assess a possible role of the amino acid sequence found in the supposed IL-1 receptor binding sites, we determined the antagonistic effects of alpha-melanocyte-stimulating hormone (MSH) and the carboxyl-terminal tripeptide of alpha-MSH-(11-13) (alpha-MSH-(11-13)) on the anorexia induced by intracerebroventricular (i.c.v.) administration of 0.5 pmol IL-1. The parent alpha-MSH molecule completely prevented the induction of anorexia by IL-1 at both doses tested, 0.5 and 5.0 pmol. In contrast, alpha-MSH-(11-13) prevented the IL-1-induced anorexia only at 5.0 pmol, but not at 0.5 pmol. Intracerebroventricular injection of 5 pmol of the parent alpha-MSH molecule alone temporarily decreased food consumption at 1-2 h; 5.0 pmol of alpha-MSH-(11-13) alone did not affect food consumption. These data indicate that alpha-MSH can antagonize the anorexic effects of IL-1. The carboxyl-terminal tripeptide portion of alpha-MSH may be important for the antagonistic action of alpha-MSH on the anorexia induced by IL-1. |
| Databáze: | OpenAIRE |
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