Performance of Choline Geranate Deep Eutectic Solvent as Transdermal Permeation Enhancer: An In Vitro Skin Histological Study
| Autor: | Victor M. Balcão, Marta M. D. C. Vila, Erika Leão Ajala Caetano, Rodrigo Boscariol, Raquel M. Rosa-Castro, Erica C. Silva, Thais J. Oliveira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences Skin barrier Chromatography Chemistry Biomolecule Pharmaceutical Science lcsh:RS1-441 02 engineering and technology histological changes 021001 nanoscience & nanotechnology In vitro Article Deep eutectic solvent Transdermal permeation lcsh:Pharmacy and materia medica transdermal permeation 03 medical and health sciences chemistry.chemical_compound Choline 0210 nano-technology Enhancer choline geranate deep eutectic solvent 030304 developmental biology Transdermal |
| Zdroj: | Pharmaceutics Pharmaceutics, Vol 13, Iss 540, p 540 (2021) Volume 13 Issue 4 |
| ISSN: | 1999-4923 |
| Popis: | In the present research work, we addressed the changes in skin by which deep eutectic solvents (DES) enhanced transdermal permeation of bioactive compounds and propose a rationale for this mechanism. Several studies showed that these unusual liquids were ideal solvents for transdermal delivery of biomolecules, but to date, no histological studies relating the action of DES to changes in the structure of the outer skin barrier have been reported. In the research effort described herein, we presented an in-depth analysis of the changes induced in the skin by choline geranate DES, a compound with proven capabilities of enhancing transdermal permeation without deleterious impacts on the cells. The results obtained showed that a low percentage of DES acted as a transient disruptor of the skin structure, facilitating the passage of bioactive compounds dissolved in it. |
| Databáze: | OpenAIRE |
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