Tumour budding in pancreatic cancer revisited: validation of the ITBCC scoring system
| Autor: | Inti Zlobec, Silvia Cibin, Alessandro Lugli, Martin Wartenberg, Beat Gloor, Mathias Worni, Evanthia Karamitopoulou |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Histology Kaplan-Meier Estimate Malignancy Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Pancreatic cancer medicine Humans Stage (cooking) 610 Medicine & health Aged Proportional Hazards Models Aged 80 and over business.industry Incidence (epidemiology) Hazard ratio Cancer General Medicine Middle Aged Prognosis medicine.disease Confidence interval Pancreatic Neoplasms 030104 developmental biology 030220 oncology & carcinogenesis 570 Life sciences biology Female Histopathology business Carcinoma Pancreatic Ductal |
| DOI: | 10.7892/boris.121738 |
| Popis: | AIMS Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with rising incidence. Biomarkers that would help the prognostic stratification of patients are needed urgently. Although tumour budding (BD) is a strong and independent prognostic factor in PDAC it is not included in histopathology reports, due partly to the lack of a standardised scoring system. The aim of the present work is to assess the reliability and reproducibility of the BD scoring system proposed recently by the International Tumour Budding Consensus Conference (ITBCC) 2016 in a well-characterised PDAC cohort (n = 120) with complete clinicopathological and follow-up information. METHODS AND RESULTS BD was scored independently by two pathologists on haematoxylin and eosin-stained PDAC sections by assessing the densest budding area at ×20 magnification (one hot-spot, 0.785 mm ), regardless of intra- or peritumoural localisation, and assigned to four categories: BD0: no buds; BD1: one to four buds; BD2: five to nine buds; and BD3: ≥ 10 buds. Findings were correlated to patient and tumour characteristics and interobserver agreement was assessed. The weighted kappa value for BD category was 0.62 (0.5-0.73), indicating strong agreement. Increasing BD category (BD3 versus BD0-2) correlated with higher grade (P = 0.002) and shorter overall [OS, P |
| Databáze: | OpenAIRE |
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