Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection
| Autor: | Alireza Davoudi, Mohsen Aarabi, Hamideh Izadyar, Fatemeh Ahangarkani, Narges Najafi, Zahra Salar, Narges Vaseghi, Atefeh Tayebi, Leila Delavarian, Zahra Daftarian, Roja Nikaeen |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study Infectious and parasitic diseases RC109-216 030204 cardiovascular system & hematology Iran Lower risk Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Medical microbiology Internal medicine Severity of illness Vitamin D and neurology Medicine Humans 030212 general & internal medicine Infectious disease (athletes) Vitamin D Aged Calcifediol Retrospective Studies business.industry SARS-CoV-2 Research COVID-19 Retrospective cohort study Length of Stay Middle Aged Vitamin D Deficiency Hospitals Hospitalization Coronavirus Insufficiency Infectious Diseases Cross-Sectional Studies COVID-19 Nucleic Acid Testing Tropical medicine Female business Sufficiency |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-7 (2021) |
| ISSN: | 1471-2334 |
| Popis: | Background A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. Methods In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. Results One hundred fifty-three patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. The vitamin D levels of the patients were 27.19 ± 20.17 ng/mL. In total, 62.7% (n = 96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. The univariate and multivariable regression showed that vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization and severity of infection (P > 0.05). Conclusions Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19. Chronic disorders in COVID-19 patients were found to have greater relevance than vitamin D levels in determining the adverse outcomes of the infection. Further studies are needed to determine the role of vitamin D level in predicting the outcomes of COVID-19 infection. |
| Databáze: | OpenAIRE |
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