Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress

Autor: Garrett Enten, Abdullah Abou-Samra, Simona Mrakic Sposta, Sandro Malacrida, Alessandra Vezzoli, Alex Rizzato, Gerardo Bosco, Enrico M. Camporesi, Giuliano Vezzani, Silvia Quartesan
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Interleukin-1beta
Avascular necrosis
medicine.disease_cause
Oxygen
0302 clinical medicine
Femur Head Necrosis
Drug Discovery
Medicine
chemistry.chemical_classification
Hyperbaric Oxygenation
biology
General Medicine
IL-1?
IL-6
Reactive oxygen species
TNF-?
femoral head necrosis
Middle Aged
medicine.anatomical_structure
IL-1β
030220 oncology & carcinogenesis
Anesthesia
Tumor necrosis factor alpha
medicine.symptom
Inflammation Mediators
Research Paper
Adult
chemistry.chemical_element
Inflammation
IL–6
TNF-α
Biomarkers
Humans
Interleukin-6
Reactive Oxygen Species
Tumor Necrosis Factor-alpha
Oxidative Stress
Pharmacology
Drug Discovery3003 Pharmaceutical Science
03 medical and health sciences
Femoral head
Interleukin 6
business.industry
lcsh:RM1-950
medicine.disease
lcsh:Therapeutics. Pharmacology
030104 developmental biology
chemistry
biology.protein
business
Oxidative stress
Zdroj: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1501-1505 (2018)
Journal of enzyme inhibition and medicinal chemistry
33 (2018): 1501–1505. doi:10.1080/14756366.2018.1485149.
info:cnr-pdr/source/autori:Gerardo Bosco a, Giuliano Vezzani a, Simona Mrakic Sposta b, Alex Rizzato a, Garrett Enten c, Abdullah Abou-samra d, Sandro Malacrida a, Silvia Quartesan a, Alessandra Vezzoli b and Enrico Camporesi c/titolo:Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress./doi:10.1080%2F14756366.2018.1485149./rivista:Journal of enzyme inhibition and medicinal chemistry (Print)/anno:2018/pagina_da:1501/pagina_a:1505/intervallo_pagine:1501–1505/volume:33
ISSN: 1475-6374
1475-6366
DOI: 10.1080/14756366.2018.1485149.
Popis: Early stages of avascular necrosis of the femoral head (AVNFH) can be conservatively treated with hyperbaric oxygen therapy (HBOT). This study investigated how HBOT modulates inflammatory markers and reactive oxygen species (ROS) in patients with AVNFH. Twenty-three male patients were treated with two cycles of HBOT, 30 sessions each with a 30 days break between cycles. Each session consisted of 90 minutes of 100% inspired oxygen at 2.5 absolute atmospheres of pressure. Plasma levels of tumor necrosis factor alfa (TNF-α), interleukin 6 (IL-6), interleukin 1 beta (IL-1β) and ROS production were measured before treatment (T0), after 15 and 30 HBOT sessions (T1 and T2), after the 30-day break (T3), and after 60 sessions (T4). Results showed a significant reduction in TNF-α and IL-6 plasma levels over time. This decrease in inflammatory markers mirrored observed reductions in bone marrow edema and reductions in patient self-reported pain.
Databáze: OpenAIRE
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