Role of specimen US for predicting resection margin status in breast conserving therapy
| Autor: | Coi L, Introna T, Cirili A, Giuseppe Angelelli, Stabile Ianora Aa, M. Moschetta, Ranieri, Leonarda Rella, Michele Telegrafo |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Breast surgery medicine.medical_treatment Breast Neoplasms Mastectomy Segmental Sensitivity and Specificity Breast cancer Predictive Value of Tests medicine Carcinoma Humans Mucinous carcinoma Aged Ultrasonography Aged 80 and over business.industry Carcinoma Ductal Breast Middle Aged medicine.disease Adenocarcinoma Mucinous Surgery Carcinoma Lobular Treatment Outcome Italy Invasive lobular carcinoma Predictive value of tests Resection margin Original Article Female Radiology business Mastectomy |
| Zdroj: | Giornale di Chirurgia - Journal of Surgery. |
| ISSN: | 1971-145X |
| DOI: | 10.11138/gchir/2015.36.5.201 |
| Popis: | Aim To assess the diagnostic accuracy of specimen ultrasound (US) for predicting resection margin status in women undergoing breast conserving therapy for US-detected cancer, having the histological findings as the reference standard. Patients and methods A total of 132 consecutive patients (age range, 34-87 years; mean, 51 years) underwent breast-conserving surgery for US-detected invasive breast cancer. All surgical specimens underwent US examination. The presence of lesion within the specimen and its distance from the specimen margins were assessed considering a threshold distance between the lesion and specimen margins of 10 mm. US findings were then compared with the pathological ones and specimen US. Sensitivity, specificity, diagnostic accuracy, positive (PPV) and negative predictive values (NPV) for predicting histological margin status were evaluated, having the histological findings as the reference standard. Results The histological examination detected invasive ductal carcinoma in 96/132 (73%) cases, invasive lobular carcinoma in 32/132 (24%), mucinous carcinoma in 4/132 (3%). The pathological margin analysis revealed 96/132 (73%) negative margins and 36 (27%) close/positive margins. US examination detected all 132 breast lesions within the surgical specimens. 110 (83%) negative margins and 22 (17%) positive margins were found on US. Sensitivity, specificity, diagnostic accuracy, PPV and NPV of 44%, 94%, 80%, 73% and 82%, respectively, were found for specimen US. Conclusions Specimen US represents a time and cost saving imaging tool for evaluating the presence of US detected-breast lesion within surgical specimen and for predicting the histological margin status. |
| Databáze: | OpenAIRE |
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