The stability and the stabilization of testicular hyaluronidase

Autor:	James W. Cassidy, Florence Valentine, Sibylle Tolksdorf, D. Roy McCullagh
Rok vydání:	1949
Předmět:	chemistry.chemical_classification Aqueous solution Chromatography Enzyme Chemistry Hyaluronidase medicine Hyaluronoglucosaminidase Testicular hyaluronidase General Biochemistry Genetics and Molecular Biology medicine.drug
Zdroj:	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 71(2)
ISSN:	0037-9727
Popis:	Summary1. Testicular hyaluronidase in bulk assaying 150 TRU per mg is stable at room temperature for more than one year.2. Hyaluronidase in concentrated aqueous solution is stable for several months at 10°.C Dilute solutions of the enzyme are less stable.3. Hyaluronidase dried from the frozen state in vials can be stabilized by the addition of polypeptide. Its half-life at 60°C is thereby extended 10 to 20 times.4. Certain bacteriostatic agents can be used throughout the production of hyaluronidase without decreasing the activity of the enzyme.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7ffa086685e8e42ce64d990caed70b https://pubmed.ncbi.nlm.nih.gov/18134042 Zobrazit plný text záznamu