Structure of Interneuronal Contacts in the Neuropil of the Oculomotor Nuclei in Mouse Brain under Conditions of Long-Term Microgravity
| Autor: | L. L. Pavlik, R. Sh. Shtanchaev, N. A. Pen’kova, I. B. Mikheeva |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Neuropil genetic structures Biology General Biochemistry Genetics and Molecular Biology Oculomotor nucleus 03 medical and health sciences Mice 0302 clinical medicine Interneurons medicine Animals Axon Weightlessness Brain General Medicine Dendrites Axons Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system Synapses Ultrastructure Functional activity sense organs Neuroscience 030217 neurology & neurosurgery Biosatellite |
| Zdroj: | Bulletin of experimental biology and medicine. 165(4) |
| ISSN: | 1573-8221 |
| Popis: | Ultrastructure of the neuropil of the brain oculomotor nuclei was studied in mice after 30-day exposure to microgravity on Bion-M1 biosatellite and after 13-h exposure to Earth gravity. The number of axo-dendritic synapses in the neuropil of the oculomotor nucleus significantly decreased after the flight. Degenerated axon terminals containing conglomerates of presynaptic vesicles appeared. The number of synapses with high functional activity increased and the length of active zones of the axo-dendritic synapses significantly increased. The observed ultrastructural changes of the neuropil of the oculomotor nuclei of mice exposed to microgravity reflect the development of long-term deafferentation of the analyzed brain structures. These changes in the neuropil ultrastructure can determine the disturbances in the oculomotor system, e.g. development of atypical nystagmus under conditions of microgravity. |
| Databáze: | OpenAIRE |
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