Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex
| Autor: | Jeffrey W. Dalley, Trevor W. Robbins, Barry J. Everitt, Kerrie L. Thomas, S. Granon, Filippo Passetti |
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| Přispěvatelé: | Department of Experimental Psychology, University of Cambridge, University of Cambridge [UK] (CAM) |
| Předmět: |
Male
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Dopamine Agents MESH: Cognition MESH: Receptors Dopamine D1 MESH: Dose-Response Relationship Drug chemistry.chemical_compound 0302 clinical medicine Cognition MESH: Animals Attention Prefrontal cortex MESH: Dopamine Agonists 0303 health sciences SCH-23390 [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior General Neuroscience Dopaminergic [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Receptor antagonist MESH: Rats Inbred Strains MESH: 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine Dopamine Agonists MESH: Benzazepines 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine Psychology MESH: Dopamine Antagonists medicine.drug Agonist medicine.medical_specialty MESH: Sulpiride MESH: Rats medicine.drug_class MESH: Dopamine Agents Prefrontal Cortex 03 medical and health sciences Dopamine receptor D1 Internal medicine medicine Animals ARTICLE 030304 developmental biology MESH: Attention Dose-Response Relationship Drug Receptors Dopamine D1 Antagonist Rats Inbred Strains Benzazepines MESH: Male Rats Endocrinology chemistry nervous system Dopamine Antagonists MESH: Prefrontal Cortex Sulpiride Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Europe PubMed Central Scopus-Elsevier Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2000, 20 (3), pp.1208-15. ⟨10.1523/JNEUROSCI.20-03-01208.2000⟩ ResearcherID |
| ISSN: | 0270-6474 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.20-03-01208.2000⟩ |
| Popis: | International audience; The role in spatial divided and sustained attention of D1 and D2-like dopamine (DA) receptors in the rat prelimbic medial prefrontal cortex (mPFC) was investigated in a five-choice serial reaction time task. Rats were trained to detect brief flashes of light (0.5-0.25 sec) presented randomly in a spatial array of five apertures. When performance stabilized, animals received bilateral microinfusions of either the D1 DA receptor antagonist SCH 23390, the D1 DA receptor agonist SKF 38393, or the D2 DA antagonist sulpiride into the mPFC. Rats were divided into two groups, with low (75%) baseline levels of accuracy. Infusions of the D2 receptor antagonist sulpiride had no significant effect on any task variable. SCH 23390 (0.3 microg) selectively impaired the accuracy of attentional performance in rats in the high baseline condition. By contrast, SKF 38393 (0.06 microg) enhanced the accuracy of attentional performance in the low baseline condition, a lower dose (0.03 microg) also increasing the speed of making correct responses. Finally, the beneficial effects of SKF-383893 on choice accuracy were antagonized by SCH 23390 (1.0 microg). The results provide apparently the first demonstration of enhanced cognitive function after local administration of a D1 receptor agonist to the mPFC and suggest dissociable roles of D1 and D2 DA receptors of the mPFC in modulating attentional function. |
| Databáze: | OpenAIRE |
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