Factors associated with seizure development after bupropion overdose: a review of the toxicology investigators consortium
| Autor: | Colin T Prather, Robert G. Hendrickson, Tony Rianprakaisang, Brian Patrick Murray, Amber Lin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Adolescent medicine.drug_class Pharmacology Toxicology Aminoketone Young Adult 03 medical and health sciences 0302 clinical medicine Seizures Tachycardia health services administration mental disorders medicine Humans Ingestion 030212 general & internal medicine Seizure activity Bupropion Aged business.industry food and beverages 030208 emergency & critical care medicine General Medicine Middle Aged Toxicity behavior and behavior mechanisms Antidepressive Agents Second-Generation Antidepressant Drug Overdose business psychological phenomena and processes medicine.drug |
| Zdroj: | Clinical Toxicology. 59:1234-1238 |
| ISSN: | 1556-9519 1556-3650 |
| Popis: | Bupropion is an aminoketone antidepressant. A major concern in bupropion toxicity is seizure activity, which can occur up to 24 h from ingestion. It is difficult to predict which patients will have seizures. The purpose of this study is to identify clinical features associate with seizure after bupropion overdose.We searched the Toxicology Investigators Consortium registry for a cases of poisoning by bupropion between January 1, 2014 and January 1, 2017 in patients aged 13-65. Demographic variables and clinical features were compared between patients who did and did not experience a seizure and presented as unadjusted odds ratios (OR). Multivariable logistic regression was used to calculate adjusted odds ratios (aOR) between clinical features and seizures.There were 256 cases of bupropion overdose remaining after inclusion/exclusion criteria were applied. Clinical features associated with seizure were QTc500 (OR = 3.4, 95% CI: 1.3-8.8,Based on our analysis of data from the ToxIC registry, age (13-18), tachycardia ( |
| Databáze: | OpenAIRE |
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