Regulation of adrenal vascular tone: Role of endothelin–1 and nitric oxide
| Autor: | Supriya Kapas, Joy P. Hinson, L.A. Cameron |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Endothelin Receptor Antagonists
Male medicine.medical_specialty Endogeny Vasodilation Nitric Oxide Peptides Cyclic Nitric oxide chemistry.chemical_compound Endocrinology Internal medicine Adrenal Glands medicine Animals Enzyme Inhibitors Rats Wistar Endothelin-1 Adrenal gland business.industry Antagonist General Medicine Endothelin 1 Rats NG-Nitroarginine Methyl Ester medicine.anatomical_structure chemistry Vasoconstriction cardiovascular system Nitric Oxide Synthase medicine.symptom business Endothelin receptor |
| Zdroj: | Endocrine Research. 22:875-879 |
| ISSN: | 1532-4206 0743-5800 |
| Popis: | The adrenal gland is a highly vascular organ, with a highly conserved and well-regulated blood supply. This study was designed to determine the roles of the local vascular regulators, nitric oxide (NO) and endothelin-1 (ET-1), in the regulation of adrenal vascular tone. Using the in situ intact perfused rat adrenal preparation it was found that the ETA receptor antagonist, BQ123, caused a significant increase in perfusion medium flow rate, while the ETB antagonist, RES-701-1, had no effect. Administration of the NO synthesis, inhibitor, L-NAME, or perfusing medium lacking the substrate for NO synthesis, resulted in a significant decrease in perfusion medium flow rate through the adrenal gland. These results suggest that endogenous endothelin causes a tonic vasoconstriction in the rat adrenal gland, mediated by the ETA receptor and that endogenous NO exerts a tonic vasodilatory effect on the rat adrenal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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