The effect of coenzyme Q10 on the regeneration of crushed facial nerve
| Autor: | Güler Berkiten, Gürcan Sünnetçi, Yavuz Uyar, Yusuf Ozturkcu, Tolgar Lütfi Kumral, Guven Yildirim, Gulcin Kamali, Ziya Saltürk |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Ubiquinone
medicine.medical_treatment Facial Paralysis Stimulation Hyperemia Antioxidants Rats Sprague-Dawley chemistry.chemical_compound Random Allocation medicine Animals Saline Myelin Sheath Coenzyme Q10 Facial Nerve Injuries Palsy business.industry Right facial nerve Significant difference General Medicine medicine.disease Facial nerve Facial paralysis Electric Stimulation Nerve Regeneration Rats Otorhinolaryngology chemistry Electron Transport Chain Complex Proteins Anesthesia Sensory Thresholds Vacuoles Surgery Female business |
| Zdroj: | The Journal of craniofacial surgery. 26(1) |
| ISSN: | 1536-3732 |
| Popis: | OBJECTIVE The aim of this study is to show the possible positive effect of coenzyme Q10 (Co Q10) on regenerating in facial palsy. MATERIALS AND METHODS Sixteen female Sprague-Dawley albino rats were randomly divided into 2 groups as Co Q10 and control groups. Group Q10 (n = 8) received Co Q10 of 10 mg/kg/d intraperitoneally for 30 days, and group C (n = 8) received saline solution of 1 mL/d intraperitoneally once daily for 30 days. The right facial nerve stimulation thresholds were determined before crush, immediately after crush, and after 1 month.After determination of the thresholds, the crushed part of the facial nerve was then excised. All specimens were examined by a pathologist using a light microscope. RESULTS No statistically significant difference in stimulation threshold was found between the Co Q10 and saline groups after crushing (P = 0.645). After 1 month of treatment, stimulation thresholds were significantly lower in both the Co Q10 and saline groups (Ps = 0.028 and 0.016). However, the Co Q10 group showed greater improvement than the saline group (P = 0.050).After 1 month of treatment, neither the Co Q10 group nor the saline group had reached the precrushing amplitude levels (Ps = 0.027 and 0.011).Significant differences were found in vascular congestion, macrovacuolization, and myelin thickness between the Co Q10 and control groups by light microscopy (P < 0.05). CONCLUSIONS Although many treatment methods have been tried to accelerate facial nerve regeneration after trauma, a definitive method has not been found yet. Co Q for the treatment of acute facial paralysis is promising on both physiologic assessments and pathologic evaluation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|