3D Printing of Diffuse Low-Grade Gliomas Involving Eloquent Cortical Areas and Subcortical Functional Pathways: Technical Note

Autor: Juan Francisco Martín-Rodríguez, Jose Luis Narros, Jose Gomez-Feria, Ignacio Martin Schrader, Gorka Gómez Ciriza, Pablo Mir, Florinda Roldan-Lora
Přispěvatelé: Instituto de Salud Carlos III, European Commission, Junta de Andalucía, Fundación Alicia Koplowitz, Ministerio de Ciencia e Innovación (España), Ministerio de Educación, Cultura y Deporte (España), Universidad de Sevilla
Rok vydání: 2020
Předmět:
Male
Models
Anatomic
Patient-Specific Modeling
Pyramidal Tracts
Surgical planning
Neurosurgical Procedures
Intraoperative Period
0302 clinical medicine
Neural Pathways
Brain tumor model
Brain Mapping
medicine.diagnostic_test
Brain Neoplasms
Technical note
3D printing
Glioma
Magnetic Resonance Imaging
Diffusion tensor imaging
Diffusion Tensor Imaging
030220 oncology & carcinogenesis
Printing
Three-Dimensional
Female
Neurosurgery
Adult
medicine.medical_specialty
Task-based functional MRI
education
Astrocytoma
03 medical and health sciences
Young Adult
Physical medicine and rehabilitation
Patient Education as Topic
Functional neuroimaging
medicine
Humans
Wernicke Area
Wakefulness
Head model
business.industry
Functional Neuroimaging
Magnetic resonance imaging
Surgical training
Broca Area
Diffusion tensor imaging tractography
Surgery
Neurology (clinical)
Neoplasm Grading
business
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 1878-8769
Popis: [Background] Surgical resection of diffuse low-grade gliomas (DLGGs) involving cortical eloquent areas and subcortical functional pathways represents a challenge in neurosurgery. Patient-specific, 3-dimensional (3D)-printed models of head and brain structures have emerged in recent years as an educational and clinical tool for patients, doctors, and surgical residents.
[Methods] Using multimodal high-definition magnetic resonance imaging data, which incorporates information from specific task-based functional neuroimaging and diffusion tensor imaging tractography and rapid prototyping technologies with specialized software and “in-house” 3D printing, we were able to generate 3D-printed head models that were used for preoperative patient education and consultation, surgical planning, and resident training in 2 complicated DLGG surgeries.
[Results] This 3D-printed model is rapid prototyped and shows a means to model individualized, diffuse, low-level glioma in 3D space with respect to cortical eloquent areas and subcortical pathways. Survey results from 8 surgeons with different levels of expertise strongly support the use of this model for surgical planning, intraoperative surgical guidance, doctor-patient communication, and surgical training (>95% acceptance).
[Conclusions] Spatial proximity of DLGG to cortical eloquent areas and subcortical tracts can be readily assessed in patient-specific 3D printed models with high fidelity. 3D-printed multimodal models could be helpful in preoperative patient consultation, surgical planning, and resident training.
Funding for this technical paper was received from the Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (PI14/01823, PI16/01575, PI18/01898, PI19/01576), Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía (CVI-02526, CTS-7685), Consejería de Salud y Bienestar Social de la Junta de Andalucía (PI-0471–2013, PE-0210–2018, PI-0459–2018, PE-0186–2019), the Fundación Alicia Koplowitz and the Spanish Ministry of Science and Innovation “Retos Colaboración” 2019 program (TC2019–007150–1). Jose Gomez-Feria Ferreiro is supported by the Spanish Ministry of Education, Culture and Sports (FPU16/03550). The Hospital Virgen del Rocío Fabrication Laboratory is partially funded by (PIN-0213–2018) 3D printing Laboratory for Andalusian Public Health Service. Juan F Martín-Rodríguez is supported by the VI-PPIT-US from the University of Seville (USE-18817-A).
Databáze: OpenAIRE
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