Hypoglossal nerve stimulation in a pre-clinical anesthetized rabbit model relevant to OSA
| Autor: | Girriso F. Benderro, Jonathan Z. Baskin, Kingman P. Strohl, Yeritza Hernandez, Jenniffer Gamble, Matthew A. Schiefer |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Hypoglossal Nerve Physiology medicine.medical_treatment Biophysics Stimulation 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Airway resistance Tongue Animals Medicine Anesthesia Saline Endoscopes Sleep Apnea Obstructive Electromyography business.industry Airway Resistance General Neuroscience Hyoid Bone Anatomy medicine.disease Trunk Electric Stimulation Obstructive sleep apnea Disease Models Animal Rabbit model Rabbits Larynx business Airway Hypoglossal nerve 030217 neurology & neurosurgery |
| Zdroj: | Respir Physiol Neurobiol |
| ISSN: | 1569-9048 |
| Popis: | We tested the functional effects of hypoglossal (CNXII) stimulation in the anesthetized rabbit before and after injections of saline into the tongue base to obstruct the airway. Data (n = 6) show little or no effect of CN XII trunk stimulation; however, medial branch stimulation (20–100 Hz; 50–500 μs pulse width, and incremental increases from 10 μA) reduced upper airway resistance. Medial branch stimulation was less effective in reducing resistance than anterior advancement of the hyoid. Endoscopic viewing (n-3) of the retropalate showed this region as the narrowest and dynamically changed by anterior hyoid displacement, with less evident effects than CNXII stimulation. We conclude that under these conditions CNXII medial branch stimulation reduces airway resistance, especially after induced obstruction. |
| Databáze: | OpenAIRE |
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