Curving Cells Inside and Out: Roles of BAR Domain Proteins in Membrane Shaping and Its Cellular Implications
Autor: | Andrew Callan-Jones, Mijo Simunovic, Emma Evergren, Patricia Bassereau |
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Rok vydání: | 2019 |
Předmět: |
Endosome
Context (language use) Biology Endocytosis Cell Membrane Structures Domain (software engineering) Cell membrane 03 medical and health sciences 0302 clinical medicine Protein Domains Neoplasms medicine Animals Humans BAR domain Cell Shape 030304 developmental biology Organelles 0303 health sciences Endoplasmic reticulum Cell Membrane Membrane Proteins Cell Biology Cell biology medicine.anatomical_structure Amphiphysin Carrier Proteins 030217 neurology & neurosurgery Developmental Biology |
Zdroj: | Annual Review of Cell and Developmental Biology. 35:111-129 |
ISSN: | 1530-8995 1081-0706 |
Popis: | Many cellular processes rely on precise and timely deformation of the cell membrane. While many proteins participate in membrane reshaping and scission, usually in highly specialized ways, Bin/amphiphysin/Rvs (BAR) domain proteins play a pervasive role, as they not only participate in many aspects of cell trafficking but also are highly versatile membrane remodelers. Subtle changes in the shape and size of the BAR domain can greatly impact the way in which BAR domain proteins interact with the membrane. Furthermore, the activity of BAR domain proteins can be tuned by external physical parameters, and so they behave differently depending on protein surface density, membrane tension, or membrane shape. These proteins can form 3D structures that mold the membrane and alter its liquid properties, even promoting scission under various circumstances.As such, BAR domain proteins have numerous roles within the cell. Endocytosis is among the most highly studied processes in which BAR domain proteins take on important roles. Over the years, a more complete picture has emerged in which BAR domain proteins are tied to almost all intracellular compartments; examples include endosomal sorting and tubular networks in the endoplasmic reticulum and T-tubules. These proteins also have a role in autophagy, and their activity has been linked with cancer. Here, we briefly review the history of BAR domain protein discovery, discuss the mechanisms by which BAR domain proteins induce curvature, and attempt to settle important controversies in the field. Finally, we review BAR domain proteins in the context of a cell, highlighting their emerging roles in cell signaling and organelle shaping. |
Databáze: | OpenAIRE |
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