Vasomotor, urogenital, psychological, and somatic symptoms in association with CYP1B1 polymorphisms in Slovak women of different menopausal status
| Autor: | Marta Cvíčelová, Lenka Vorobeľová, Daniela Siváková, Veronika Čerňanová, Zuzana Dankova |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Slovakia Health Status Urogenital System 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Genetics medicine Menopausal Symptom Humans 030212 general & internal medicine Risk factor Exercise Reproductive History Ecology Evolution Behavior and Systematics 030219 obstetrics & reproductive medicine Polymorphism Genetic Vasomotor Genitourinary system business.industry Smoking Anthropometry Middle Aged medicine.disease Menopause Vasomotor System Medically Unexplained Symptoms Anthropology Cytochrome P-450 CYP1B1 Female Anatomy business Bioelectrical impedance analysis Stress Psychological |
| Zdroj: | American journal of human biology : the official journal of the Human Biology Council. 30(3) |
| ISSN: | 1520-6300 |
| Popis: | OBJECTIVES The aim of this study was to examine if the Arg48Gly, Ala119Ser, Leu432Val, and Asn453Ser polymorphisms in the CYP1B1 estrogen-metabolizing gene are associated with menopausal symptom experience in healthy Slovak women aged 40-60 years. We also investigated the possible association of other factors with menopausal symptoms, including health status, physical activity, reproductive history, psychological status, and smoking. METHODS The total sample consisted of 367 women (mean age 49.11 ± 5.86 years), encompassing 180 premenopausal (mean age 45.06 ± 3.81 years), 29 peri-menopausal (mean age 49.41 ± 3.94 years), and 158 postmenopausal (mean age 53.71 ± 4.54 years) women. The research comprised anthropometric and bioelectrical impedance analysis measurements (BIA), blood or saliva samples collected for DNA analysis, and a specific menopausal questionnaire. RESULTS CYP1B1 Arg48Gly is significantly associated with vasomotor, psychological, and somatic symptoms. It appears that the Gly/Gly genotype is a risk factor during the postmenopause and protective in the pre- and peri-menopause. CYP1B1 Ala119Ser was associated with all menopausal symptoms, with the Ser/Ser genotype increasing risk in the premenopause and offering protection in the peri- and postmenopause. Polymorphisms Leu432Val and Asn453Ser gave unequivocal results; independent of menopausal status, the Leu/Leu genotype was associated with increasing risk of vasomotor, urogenital, and psychological symptoms and the Asn/Asn genotype provided a protective effect against psychological symptoms. CONCLUSIONS Our results suggest possible associations of CYP1B1 polymorphisms with the occurrence and manifestation of particular menopausal symptoms in healthy mid-life Slovak women. |
| Databáze: | OpenAIRE |
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