Severity of Nausea and Vomiting in Singleton and Twin Pregnancies in Relation to Fetal Sex: The Japan Environment and Children’s Study (JECS)
| Autor: | Narufumi Suganuma, Masamitsu Eitoku, Mikiya Fujieda, Nagamasa Maeda, Naomi Mitsuda |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male JECS medicine.medical_specialty Vomiting Epidemiology Nausea 030209 endocrinology & metabolism nausea and vomiting during pregnancy Logistic regression Severity of Illness Index Cohort Studies Young Adult 03 medical and health sciences Sex Factors Maternal and Child Health 0302 clinical medicine Japan Pregnancy Risk Factors immune system diseases Fetal sex Humans Medicine 030212 general & internal medicine lcsh:R5-920 business.industry Obstetrics Singleton virus diseases General Medicine medicine.disease Pregnancy Complications multiple birth fetal sex Pregnancy Twin Female Original Article twin Multiple birth medicine.symptom lcsh:Medicine (General) business Birth plurality |
| Zdroj: | Journal of Epidemiology Journal of Epidemiology, Vol 29, Iss 9, Pp 340-346 (2019) |
| ISSN: | 1349-9092 0917-5040 |
| Popis: | Background Some studies have indicated that female birth and multiple births were risk factors for nausea and vomiting during pregnancy (NVP). The results, however, were conflicting. Our study was conducted to evaluate the association of maternal NVP with fetal sex in singleton and twin pregnancies. Methods We used the data set from a birth cohort study, the Japan Environment and Children's Study (JECS). In the self-administered questionnaire, participants were asked whether they experienced NVP prior to 12 gestational weeks. Main outcome measures were the presence of NVP and severity of NVP. We estimated the association of fetal sex and birth plurality with NVP using logistic regression analysis, followed by interaction analysis. Results Of 91,666 women, 75,828 (82.7%) experienced at least some symptoms of NVP and 10,159 (11.1%) experienced severe NVP. Women with female pregnancies and twin pregnancies had higher odds for the presence of NVP and severe NVP compared to women with male pregnancies and singleton pregnancies, respectively. Moreover, of mothers with twin pregnancies, higher odds for the presence of NVP and severe NVP were reported when one or both infants were female, compared to those in which both infants were male. There was no significant interaction between fetal sex and birth plurality. Conclusions Female sex birth and multiple births are risk factors for the presence of NVP, and especially for severe NVP without interaction. These findings suggest that a factor abundant in the female fetus associates with the severity of NVP. |
| Databáze: | OpenAIRE |
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