The thiol/disulfide balance in ketone positive and ketone negative pregnant women with nausea and vomiting - a prospective study in a tertiary center
| Autor: | Ozcan Erel, Nurullah Peker, Cagdas Ozgokce, Serhat Ege, Ruşen Köçeroğlu, Recep Yildizhan, Selami Erdem, Muhammed Hanifi Bademkıran |
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| Přispěvatelé: | Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı, Peker, Nurullah |
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Ketone Antioxidant Nausea medicine.medical_treatment Thiol/disulfide homeostasis 03 medical and health sciences Hyperemesis gravidarum 0302 clinical medicine Pregnancy Internal medicine Nausea and vomiting Hyperemesis Gravidarum medicine Humans Disulfides Prospective Studies Sulfhydryl Compounds Prospective cohort study chemistry.chemical_classification 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Ketones medicine.disease Oxidative Stress Endocrinology chemistry Oxidative stress Case-Control Studies Vomiting Thiol Female medicine.symptom business |
| Zdroj: | Ginekologia polska. 91(4) |
| ISSN: | 2543-6767 |
| Popis: | Objectives: We aimed to investigate the thiol/disulfide balance in ketone positive (hyperemesis gravidarum) and ketone negative pregnant women with nausea and vomiting. Material and methods: A total of 60 patients under the 14th week of pregnancy were included in this study, and they were divided into two groups. Group 1 included 30 pregnant women with ketone positive, group 2 included 30 ketone negative pregnant women with nausea, and vomiting. Results: The native thiol, disulfide, and total thiol concentrations were measured using an automated method and compared among the two groups. There were also three indexes that are derived from disulfide, native and total thiol (Index 1 = 100 × disulfide/native thiol); (Index 2 = 100 × disulfide/total thiol); (Index 3 = 100 × native thiol/total thiol). When compared with Group 1 and Group 2, total thiol was high, native thiol was low but not statistically significant. Disulphide (p = 0.046), index 1 (p = 0.036) and index 3 (p = 0.034) were statistically significant. Conclusions: Patients with ketone positive are shifting to OS direction due to lack of nutrients and electrolytes. This study emphasizes the therapeutic potential of antioxidant supplementation, which is becoming an increasingly used approach in treating the symptoms of women with ketone positive. |
| Databáze: | OpenAIRE |
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