Failure of Cefotaxime in the Treatment of Meningitis Due to Relatively Resistant Streptococcus pneumoniae
| Autor: | Juan Carlos López Bernaldo de Quirós, Avelina Suárez, José M. García Fernández, María José Catalán, Eduardo Varela de Seijas, Antonio Vázquez |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Microbiology (medical) Cefotaxime medicine.drug_class Penicillin Resistance Antibiotics medicine.disease_cause Meningitis Bacterial Microbiology Vancomycin Streptococcal Infections Streptococcus pneumoniae medicine Humans Injections Spinal Antibacterial agent biology business.industry Drug Resistance Microbial medicine.disease Streptococcaceae biology.organism_classification Penicillin Infectious Diseases Injections Intravenous business Meningitis medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 18:766-769 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/clinids/18.5.766 |
| Popis: | To our knowledge, we report the first failure of cefotaxime in the treatment of meningitis due to relatively resistant Streptococcus pneumoniae (MICs of penicillin and cefotaxime, 1 microgram/mL). Cure was achieved with a 14-day course of intravenous and intrathecal vancomycin. We recommend that in cases of meningitis caused by strains of S. pneumoniae for which MICs are > or = 1 microgram/mL, cefotaxime should be used with caution; however, if therapeutic failure is suspected therapy should be changed to intravenous and intrathecal vancomycin. |
| Databáze: | OpenAIRE |
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