Effect of a swim training on homocysteine and cysteine levels in rats

Autor: J. M. Alberto, J. C. Guilland, D. Alber, Vincent Gaume, Jean-Louis Guéant, Fabienne Mougin, H. Figard, Alain Berthelot, Céline Demougeot
Přispěvatelé: Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Optimisation Métabolique et Cellulaire
Rok vydání: 2005
Předmět:
Male
Taurine
MESH: Swimming
Homocysteine
Clinical Biochemistry
MESH: Rats
Sprague-Dawley
MESH: Physical Conditioning
Animal
030204 cardiovascular system & hematology
Biochemistry
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
MESH: Animals
MESH: Glutathione
0303 health sciences
biology
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Glutathione
MESH: Cystathionine beta-Synthase
Liver
Pyridoxal Phosphate
MESH: Pyridoxal Phosphate
medicine.medical_specialty
MESH: Rats
Cystathionine beta-Synthase
Acclimatization
03 medical and health sciences
Physical Conditioning
Animal
Internal medicine
medicine
Animals
MESH: Homocysteine
Cysteine
Pyridoxal
Swimming
030304 developmental biology
Organic Chemistry
Metabolism
MESH: Cysteine
Cystathionine beta synthase
MESH: Male
MESH: Taurine
Rats
Endocrinology
chemistry
biology.protein
MESH: Liver
Zdroj: Amino Acids
Amino Acids, Springer Verlag, 2005, 28 (3), pp.337-342. ⟨10.1007/s00726-004-0147-8⟩
ISSN: 1438-2199
0939-4451
DOI: 10.1007/s00726-004-0147-8
Popis: International audience; The purpose of this study was to investigate the effects of a 8-week of swim training on total plasma homocysteine and cysteine levels in 16 male Sprague-Dawley rats aged 17 weeks. We also evaluated the activity of hepatic cystathionine beta-synthase (CBS), an enzyme involved in the metabolism of Hcy, the concentration of plasma glutathione, taurine, and a fraction of vitamin B6: the pyridoxal 5-phosphate (PLP). After one week of acclimatization, rats were randomly divided into two groups: 8 non-trained (NTR) and 8 trained rats (TR). Following the training period, body weight gain was lower in TR than in NTR. Plasma homocysteine did not differ among groups while significantly lower plasma cysteine and taurine levels were found in TR (157.83 +/- 8.6 micromol/L; 133.01 +/- 9.32 micromol/L; P < 0.05) compared with data of NTR (176.19 +/- 4.9 micromol/L; 162.57 +/- 8.16 micromol/L; P < 0.05). No significant changes in hepatic CBS activity were observed in TR compared with NTR. Moreover, values for plasma glutathione and PLP concentrations were not affected by training.These results indicate that training reduces plasma cysteine and taurine levels whereas it does not modify other studied parameters. Thus, physical training may regulate cysteine metabolism.
Databáze: OpenAIRE
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