Heparin Treatment of Deep Venous Thrombosis in 280 Patients: Symptoms Related to Dosage
| Autor: | H. Asbjørn Holm, Bjørn Finnanger, Anders Hartmann, Njål Stray, Terje Wolland, Frode Lærum, Tom Erik Ruud, Odd Løhren |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Hemorrhage Thrombophlebitis Edema Internal Medicine medicine Humans Infusions Parenteral Thrombus Aged Heparin business.industry Anticoagulant Middle Aged medicine.disease Thrombosis Pulmonary embolism Surgery Venous thrombosis Anesthesia Female medicine.symptom Pulmonary Embolism business medicine.drug |
| Zdroj: | Acta Medica Scandinavica. 215:47-53 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1984.tb04968.x |
| Popis: | 280 patients with phlebographically proven deep venous thrombosis received intravenous heparin infusion, mean duration 6.8 days, mean dose 370 U/kg/day. In 58 patients (21%) there was no apparent predisposing factor. Leg pain diminished more rapidly than edema. At discharge, 46% had edema. Symptoms suggesting pulmonary embolism (PE) occurred in 13 patients (4.6%) whose mean daily heparin dose was similar to that of the others. The only fatal PE occurred three days after cessation of heparin administration. Eight patients (3%) experienced major bleeding, the only fatal occurring after thoracocentesis. The frequency of major bleeding in patients above 70 years was 8% in females and 4% in males, in those below 70 years it was 0.5%; 22 patients (8%) had minor bleeding. Control phlebography after one week revealed completely cleared thrombus in 3%, partial clearance in 36%, unchanged in 39% and increased thrombosis in 22%. Dosage was significantly correlated to thrombus resolution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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