Preferential expression of cellular retinoic acid binding protein in a subpopulation of neural cells in the developing mouse embryo
| Autor: | Christine L. Mummery, M.J. Vaessen, Erika kootwijk, Ad Geurts van Kessel, Dirk Bootsma, John Hilkens |
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| Rok vydání: | 1989 |
| Předmět: |
Cancer Research
Receptors Retinoic Acid Molecular Sequence Data Restriction Mapping Retinoic acid Retinoic acid receptor beta Tretinoin Biology Nervous System Retinoic acid-inducible orphan G protein-coupled receptor chemistry.chemical_compound Mice medicine Animals Amino Acid Sequence RNA Messenger Molecular Biology Neurons Base Sequence Binding protein Chromosome Mapping Nucleic Acid Hybridization Cell Biology Retinoic acid receptor gamma DNA Blotting Northern Molecular biology Retinoic acid receptor chemistry Retinoic acid receptor alpha Carrier Proteins Developmental Biology medicine.drug |
| Zdroj: | Differentiation; research in biological diversity. 40(2) |
| ISSN: | 0301-4681 |
| Popis: | The cellular retinoic acid binding protein is thought to be involved in the retinoic-acid-mediated signal transduction pathway. We have isolated the mouse cellular retinoic acid binding protein cDNA from an embryonal-carcinoma-derived cell line by using differential cDNA cloning strategies. In situ hybridization on sections of mouse embryos of various developmental stages indicated that the cellular retinoic acid binding protein gene, which we localized on mouse chromosome 9, is preferentially expressed in a subpopulation of neurectodermal cells. This restricted expression pattern suggests an important role for cellular retinoic acid binding protein in murine neurogenesis. |
| Databáze: | OpenAIRE |
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