The effects of treatment with atorvastatin versus rosuvastatin on endothelial dysfunction in patients with hyperlipidaemia
| Autor: | Vahit Demir, Yunus Çelik, Samet Yilmaz, Çağlar Alp, Nesligül Yildirim, Mehmet Tolga Dogru, Hüseyin Ede |
|---|---|
| Přispěvatelé: | Kırıkkale Üniversitesi |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Brachial Artery Endothelium Atorvastatin Hyperlipidemias 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine endothelial function Internal medicine Humans Medicine Rosuvastatin cardiovascular diseases 030212 general & internal medicine Rosuvastatin Calcium Endothelial dysfunction Creatinine Triglyceride business.industry Cardiovascular Topics nutritional and metabolic diseases Recovery of Function atorvastatin General Medicine Middle Aged medicine.disease Lipids Vasodilation Treatment Outcome medicine.anatomical_structure chemistry flow-mediated vasodilatation Cardiology Female lipids (amino acids peptides and proteins) Endothelium Vascular Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business rosuvastatin Body mass index Biomarkers medicine.drug Lipoprotein |
| Zdroj: | Cardiovascular Journal of Africa |
| ISSN: | 1680-0745 1995-1892 |
| Popis: | Demir, Vahit/0000-0001-8349-6651 WOS: 000457728400007 PubMed: 29528361 Introduction: Statins can reduce cardiovascular events and improve endothelial function, However. differences in the effect of statins on endothelial dysfunction have not been researched sufficiently. Here. we aimed to compare the effects of atorvastatin Versus rosuvastatin on endothelial function via flow-mediated ',aid endothelial-independent dilation. Methods: Hyperlipidaemic subjects on treatment with statins for one year (either 20 mg/day atorvastatin or 10 mg/day rosuvastatin) were enrolled in the study. In accordance with the literature, flow-mediated dilation (FMD) and nitrate-mediated endothelium-independent dilation (EID) were measured by ultrasonography on the right brachial artery of each subject. Baseline and final measurements were compa red to each group and between the groups. Results: One hundred and four subjects (50 atorvastatin and 54 rosuvastatin users) were enrolled in the study. Fifty-eight subjects were female. The groups were statistically similar in terms of age and body mass index, and haemoglobin, creatinine, total cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein cholesterol levels. In each group, the mean final FMD and LID values were higher compared to their respective baseline values. but the mean changes in FMD and EID were statistically similar in both groups (p = 0.958 for FMD and 0.827 for EID). There was no statistically significant difference between the atorvastatin and rosuvastatin groups in terms of final FMD and EID values (p = 0.122 and 0.115. respectively). Conclusion: This study demonstrated that both one-year atorvastatin and rosuvastatin treatments significantly improved endothelial function, when assessed with FMD and FAD and measured by ultrasonography. However, the amount of improvement in endothelial dysfunction was similar in the two treatments. |
| Databáze: | OpenAIRE |
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