Rotational Thromboelastometry Reveals Distinct Coagulation Profiles for Patients With COVID-19 Depending on Disease Severity
| Autor: | Olga Meltem Akay, Said Incir, Zeynep Komesli, Ozlem Yalcin, Mehmet Gokhan Gonenli |
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| Přispěvatelé: | Gönenli, Mehmet Gökhan (ORCID 0000-0003-2925-7048 & YÖK ID 350445), Komesli, Zeynep, İncir, Said, Yalçın, Özlem (ORCID 0000-0001-5547-6653 & YÖK ID 218440), Akay, Olga Meltem (ORCID 0000-0002-6759-1939 & YÖK ID 170966), Koç University Hospital, School of Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Original Manuscript thromboelastometry 030204 cardiovascular system & hematology Thrombophilia Fibrinogen Gastroenterology Severity of Illness Index coagulopathy 03 medical and health sciences 0302 clinical medicine Internal medicine Coagulopathy Medicine Diseases of the circulatory (Cardiovascular) system Humans 030212 general & internal medicine Prospective Studies COVID-19 Thromboelastometry Blood coagulation test Prothrombin time medicine.diagnostic_test business.industry SARS-CoV-2 Complete blood count Hematology General Medicine Blood Proteins Middle Aged medicine.disease Peripheral vascular disease Cardiovascular system Cardiology Blood Cell Count Thrombelastography RC666-701 Case-Control Studies Female Blood Coagulation Tests business Partial thromboplastin time medicine.drug |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021) |
| ISSN: | 1938-2723 1076-0296 |
| Popis: | Identifying a hypercoagulable state in patients with COVID-19 may help identify those at risk for virus–induced thromboembolic events and improve clinical outcomes using personalized therapeutic approaches. Herein, we aimed to perform a global assessment of the patients’ hemostatic system with COVID-19 using rotational thromboelastometry (ROTEM) and to describe whether patients with different disease severities present different coagulation profiles. Together with 37 healthy volunteers, a total of 65 patients were included and then classified as having mild, moderate, and severe disease depending on clinical severity. Peripheral blood samples were collected and analyzed using a ROTEM Coagulation Analyzer. Also, complete blood count and coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen levels, and D-dimer levels were measured at admission. EXTEM and INTEM MCF (P < 0.001) values were significantly higher and the EXTEM CFT (P = 0.002) value was significantly lower in patients with COVID-19 when compared with controls. In particular, patients with the severe disease showed a significant decrease in CFT (P < 0.001) and an increase in MCF (P < 0.001) in both INTEM and EXTEM assays compared with patients with the non-severe disease. Correlation analysis revealed significant correlations between ROTEM parameters and other coagulation parameters. There were significant positive correlations between fibrinogen, D-dimer, platelet count, and MCF in both EXTEM and INTEM assays. Our data demonstrate thromboelastographic signs of hypercoagulability in patients with COVID-19, which is more pronounced in patients with increased disease severity. Therefore, ROTEM analysis can classify subsets of patients with COVID-19 at significant thrombotic risk and assist in clinical decisions. NA |
| Databáze: | OpenAIRE |
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