Association of HLA-B22 serotype with SARS-CoV-2 susceptibility in Hong Kong Chinese patients
| Autor: | Jenny Tian Xia, Raymond S.M. Wong, Hoi Yun Chan, J. N. S. Leung, Chi Keung Cheng, Yuk Lin Yung, Kin-Mang Lau, Eudora Y.D. Chow, Margaret H.L. Ng, Sze Fai Yip, Alan K.L. Wu, Alice C.C. Wong, Raymond W. Chu, Cheuk Kwong Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Serotype
Adult Male Adolescent Immunology coronavirus Human leukocyte antigen medicine.disease_cause Brief Communication Severity of Illness Index SARS‐CoV‐2 Cohort Studies Young Adult Asian People Immunity COVID‐19 Genotype Pandemic Genetics medicine HLA-B Antigens Immunology and Allergy Humans Genetic Predisposition to Disease Immunogenetic Phenomena Pandemics Coronavirus Aged Aged 80 and over Chinese business.industry SARS-CoV-2 Histocompatibility Testing COVID-19 Middle Aged Virology HLA Infectious disease (medical specialty) Hong Kong Female business |
| Zdroj: | Hla HLA |
| ISSN: | 2059-2310 |
| Popis: | The coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by SARS-CoV-2. Since its first report in December 2019, COVID-19 has evolved into a global pandemic causing massive healthcare and socioeconomic challenges. HLA system is critical in mediating anti-viral immunity and recent studies have suggested preferential involvement of HLA-B in COVID-19 susceptibility. Here, by investigating the HLA-B genotypes in 190 unrelated Chinese patients with confirmed COVID-19, we identified a significant positive association between the B22 serotype and SARS-CoV-2 infection (p = 0.002, Bonferroni-corrected p = 0.032). Notably, the B22 serotype has been consistently linked to susceptibility to other viral infections. These data not only shed new insights into SARS-CoV-2 pathogenesis and vaccine development but also guide better infection prevention/control. |
| Databáze: | OpenAIRE |
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