Endogenous fungal endophthalmitis following intensive corticosteroid therapy in severe COVID-19 disease

Autor:	Shraddha R Pawar, Neelam Atri, Shishir Narain, Arindam Chakravarti, Arpan Gandhi, Gagan Bhatia, Ritesh Narula, Neelam Sapra, Daraius Shroff
Rok vydání:	2021
Předmět:	Pars plana medicine.medical_specialty Visual acuity genetic structures medicine.medical_treatment Visual Acuity India Vitrectomy Disease Expedited Publication Original Article Endophthalmitis Blurred vision medicine Humans Retrospective Studies business.industry SARS-CoV-2 Fungi Pars plana vitrectomy COVID-19 Floaters Retrospective cohort study RE1-994 medicine.disease Fungal endophthalmitis Corticosteroid therapy eye diseases Surgery Ophthalmology Pneumonia medicine.anatomical_structure Endogenous endophthalmitis sense organs medicine.symptom business Eye Infections Fungal
Zdroj:	Indian Journal of Ophthalmology Indian Journal of Ophthalmology, Vol 69, Iss 7, Pp 1909-1914 (2021)
ISSN:	1998-3689
Popis:	Purpose To report endogenous fungal endophthalmitis, postrecovery from severe COVID-19 infection in otherwise immunocompetent individuals, treated with prolonged systemic steroids. Methods Retrospective chart review of cases with confirmed and presumed fungal endogenous endophthalmitis, following severe COVID-19 disease, treated at two tertiary care referral eye institutes in North India. Results Seven eyes of five cases of endogenous fungal endophthalmitis were studied. All cases had been hospitalized for severe COVID-19 pneumonia and had received systemic steroid therapy for an average duration of 42 ± 25.1 days (range 18-80 days). All the cases initially complained of floaters with blurred vision after an average of 6 days (range 1-14 days) following discharge from hospital. They had all been misdiagnosed as noninfectious uveitis by their primary ophthalmologists. All eyes underwent pars plana vitrectomy (PPV) with intravitreal antifungal therapy. Five of the seven eyes grew fungus as the causative organism (Candida sp. in four eyes, Aspergillus sp. in one eye). Postoperatively, all eyes showed control of the infection with a marked reduction in vitreous exudates and improvement in vision. Conclusion Floaters and blurred vision developed in patients after they recovered from severe COVID-19 infection. They had received prolonged corticosteroid treatment for COVID-19 as well as for suspected noninfectious uveitis. We diagnosed and treated them for endogenous fungal endophthalmitis. All eyes showed anatomical and functional improvement after PPV with antifungal therapy. It is important for ophthalmologists and physicians to be aware of this as prompt treatment could control the infection and salvage vision.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5d9524ae67c2bee6201ed41988f1ed https://pubmed.ncbi.nlm.nih.gov/34146056 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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