Noninvasive Assessment of Retinal Blood Flow Using a Novel Handheld Laser Speckle Contrast Imager
| Autor: | Karan Raje, Luis Toledo, Abhishek Rege, Osamah Saeedi, Lisa S. Schocket, Sachin Kalarn, M. Jason Brooke, Asifa Shafi, Samantha I. Cunningham, Yusi Liu, Sunni Scott |
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| Rok vydání: | 2018 |
| Předmět: |
genetic structures
health care facilities manpower and services media_common.quotation_subject education Biomedical Engineering Fundus (eye) 01 natural sciences 010309 optics 03 medical and health sciences Speckle pattern 0302 clinical medicine 0103 physical sciences medicine Medical imaging Contrast (vision) Mean Blood Flow Velocity media_common laser speckle imaging ocular imaging medicine.diagnostic_test business.industry Fundus photography Laser Speckle Imaging Articles Blood flow 3. Good health Ophthalmology 030221 ophthalmology & optometry business retinal blood flow human activities Biomedical engineering |
| Zdroj: | Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Popis: | Purpose We assessed the image quality and reproducibility of blood flow measurements from a novel handheld laser speckle imager in handheld and stabilized use cases. Methods Eleven dilated human subjects were imaged with the XyCAM Handheld Retinal Imager investigational device (XyCAM HRI) in the handheld and stabilized use case in nine consecutive imaging sessions. Subjects then underwent standard color fundus photography using a Topcon TRC 50DX. The vessel-to-background contrast of the XyCAM HRI red-free photo was compared to the fundus photograph, while the coefficient of variation of blood flow measurements in specific arteries and veins also was determined. Results Vessel-to-background contrast was statistically greater in the handheld use case when compared to the standard color fundus photographs (P = 0.01). Estimates of mean blood flow velocity (BFV) were highly correlated between the stabilized and handheld use case (r2 = 0.96). Peak velocity estimates in arteries were significantly higher than those in veins (P < 0.05). Conclusions The XyCAM HRI prototype can acquire fundus photographs with the same or better level of clarity as color fundus photographs, and reproducibly acquire functional blood flow information in the handheld use case. Translational Relevance To our knowledge, this is the first human study of a handheld laser speckle retinal imaging device. Determination of retinal blood flow has applications to ophthalmic and systemic disease and a portable handheld retinal imager that determines blood flow may be widely adopted at the point of care. |
| Databáze: | OpenAIRE |
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