Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer

Autor:	Guang Yu Liu, Jiong Wu, Ben Ma, Wei bo Xu, Zhi Min Shao, Yu Wang, X. Chen, Miao Mo, Wen Jun Wei, Qinghai Ji, Nai Si Huang, Xiao Mao Guo, Shu wen Yang, Jia Ying Chen
Rok vydání:	2018
Předmět:	0301 basic medicine Oncology Male Cancer Research medicine.medical_specialty Breast Neoplasms 030105 genetics & heredity Malignancy Neoplasms Multiple Primary 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Internal medicine medicine thyroid cancer Humans Radiology Nuclear Medicine and imaging Thyroid Neoplasms synchronous cancer Risk factor Thyroid cancer Retrospective Studies Original Research business.industry Retrospective cohort study Odds ratio Middle Aged medicine.disease Standardized mortality ratio 030220 oncology & carcinogenesis Relative risk Female prognosis business Cancer Prevention second primary malignancy
Zdroj:	Cancer Medicine
ISSN:	2045-7634
Popis:	Background Thyroid cancer (TC) is one of the most commonly seen secondary malignancy in breast cancer (BC) survivors. Materials and methods A retrospective study was conducted in BC patients in our center from 1999 to 2013. Patients were divided into BC‐TC group and BC‐alone group. Results In total, 13 978 BC patients were identified, among whom 247 (1.8%) had TC. The standardized incidence ratio (SIR) of TC was 4.48 compared with Chinese females, and up to 98.0% of cases were thyroid papillary carcinomas. A family history of malignancy was the only independent risk factor (odds ratio = 1.457, P = 0.025) for development of TC in patients with BC. We also identified inferior survival in patients with synchronous versus metachronous BC‐TC (P = 0.016). Synchronous BC‐TC (risk ratio = 5.597, P = 0.018) was an independent prognostic factor for inferior RFS. Conclusions We observed high co‐occurrence of TC in patients with BC. There might be different mechanisms behind synchronous and metachronous BC‐TC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5ba238d14b2eca6a8a95f8b0d584f9 https://pubmed.ncbi.nlm.nih.gov/30480382 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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