Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet
| Autor: | Veridiana Vera de Rosso, Daniel Araki Ribeiro, Giovana Jamar, Laís Vales Mennitti, Lila Missae Oyama, Aline Boveto Santamarina, Caroline Margonato Cardoso, Luciana Pellegrini Pisani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Necrosis 030309 nutrition & dietetics Pharmaceutical Science Adipose tissue Aspartate transaminase 030209 endocrinology & metabolism Inflammation juçara liver Analytical Chemistry lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine lcsh:Organic chemistry Internal medicine Drug Discovery nutraceutical food medicine Physical and Theoretical Chemistry Euterpe edulis Liver injury 0303 health sciences biology Chemistry short-term high-fat diet Organic Chemistry biology.organism_classification medicine.disease adipose tissue Endocrinology Chemistry (miscellaneous) inflammation TLR4 biology.protein Molecular Medicine Tumor necrosis factor alpha medicine.symptom |
| Zdroj: | Molecules Volume 24 Issue 9 Molecules, Vol 24, Iss 9, p 1655 (2019) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24091655 |
| Popis: | Juç ara berry is a potential inflammatory modulator, rich in dietary fiber, fatty acids, and anthocyanins. Considering this, we evaluated the high-fat diet (HFD) intake supplemented with different doses of freeze-dried juç ara pulp on the TLR4 pathway. Twenty-seven male Wistar rats with ad libitum access to food and water were divided into four experimental groups: control standard chow group (C) high-fat diet control group (HFC) high-fat diet juç ara 0.25% group (HFJ0.25%) and high-fat diet juç ara 0.5% group (HFJ0.5%). The inflammatory parameters were analyzed by ELISA and Western blotting in liver and retroperitoneal adipose tissue (RET). The HFJ0.25% group had the energy intake, aspartate transaminase (AST) levels, and liver triacylglycerol accumulation reduced also, the tumor necrosis factor &alpha (TNF-&alpha ) and TNF receptor-associated factor 6 (TRAF6) expression in RET were reduced. However, there were no changes in other protein expressions in liver and adipose tissue. Adiposity and pNF&kappa Bp50 had a positive correlation in HFC and HFJ0.5%, but not in the C group and HFJ0.25%. The necrosis hepatic score did not change with treatment however, the serum (AST) levels and the hepatic triacylglycerol were increased in HFC and HFJ0.5%. These results demonstrated that one week of HFD intake triggered pro-inflammatory mechanisms and liver injury. Additionally, 0.25% juç ara prevented inflammatory pathway activation, body weight gain, and liver damage |
| Databáze: | OpenAIRE |
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