Trisomy 12 in chronic lymphocytic leukemia—geographical variation
| Autor: | Purvish M. Parikh, Chandrika N. Nair, Suresh H. Advani, Darshana Telang, Anuradha Chougule, Rajat Goyal, Subodh Dhond, Swati Pai |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Chronic lymphocytic leukemia India Aneuploidy Trisomy Biology CD5 Antigens Immunophenotyping Leukocyte Count White blood cell medicine Humans Lymphocytes In Situ Hybridization Fluorescence Chromosome 12 Aged Glycoproteins Chromosomes Human Pair 12 medicine.diagnostic_test Receptors IgE Incidence Hybridization probe Age Factors Cytogenetics Hematology Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell medicine.anatomical_structure Oncology Female Fluorescence in situ hybridization |
| Zdroj: | Leukemia Research. 22:313-317 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/s0145-2126(97)00169-0 |
| Popis: | Incidence of trisomy 12 was studied in 60 cases of chronic lymphocytic leukemia (CLL) with chromosome 12 specific alpha-satellite DNA probe by fluorescence in situ hybridization (FISH). Trisomy 12 was observed in 37 (61.8%) patients. Cells with trisomy 12 were detected in a varying proportion, ranging from2% to 86%. Patients with trisomy 12 were predominantly observed with total white blood cell (WBC) count80 x 10(9) l(-1) (P0.001). In addition, the percentage of trisomy 12 positive lymphocytes correlated with the high WBC counts. Trisomy 12 was observed equally in typical and atypical CLL. 90% of our patients were in the intermediate and high risk groups. It was seen that there was significantly higher percentage of trisomy 12 positive lymphocytes (10%) in the high risk groups (P0.05). A higher incidence of FMC7 positivity in atypical CLL was seen in our study. However, there was no significant relationship found between trisomy 12 positivity and expression of either FMC7 or CD23 in our cases. It appears that the CLL that we see at our centre is at a different phase of evolution and perhaps biologically different compared to the CLL seen in the West. |
| Databáze: | OpenAIRE |
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