A Controlled Study of Ranitidine for the Prevention of Recurrent Hemorrhage from Duodenal Ulcer
| Autor: | M. E. Jensen, G. M. Randall, D. M. Jensen, G. VanDeventer, J. Smith, Gustavo A. Machicado, T. Reedy, M. Silpa, S. Cheng, H. Frankl, Tog Kovacs |
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| Rok vydání: | 1994 |
| Předmět: |
Advanced and Specialized Nursing
Chemotherapy medicine.medical_specialty Gastrointestinal bleeding medicine.diagnostic_test business.industry medicine.medical_treatment Gastroenterology General Medicine Placebo medicine.disease Surgery Endoscopy Duodenal ulcer Ranitidine medicine.anatomical_structure Maintenance therapy Internal medicine medicine Duodenum Complication business Recurrent hemorrhage medicine.drug |
| Zdroj: | New England Journal of Medicine. 330:382-386 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Background Hemorrhage is the most common complication of duodenal ulcer disease, but there is little information about the effectiveness and safety of long-term maintenance therapy with histamine H2-receptor blockers. Methods We conducted a double-blind study in patients with endoscopically documented hemorrhage from duodenal ulcers. Patients were randomly assigned to maintenance therapy with ranitidine (150 mg at night) or placebo and were followed for up to three years. Endoscopy was performed at base line (to document that the ulcers had healed), at exit from the study, and when a patient had persistent ulcer symptoms unrelieved by antacids or had gastrointestinal bleeding. Symptomatic relapses without bleeding were treated with ranitidine; if the ulcer healed within eight weeks, the patient resumed taking the assigned study medication. Results The two groups were similar at entry, which usually occurred about three months after the index hemorrhage. After a mean follow-up of 61 weeks, 3 of the 32 pati... |
| Databáze: | OpenAIRE |
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