GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients
| Autor: | Mohamed M. Mohamed, Doaa Y. Ali, Noha K Abdelghaffar, Olfat G. Shaker, Amal A Ibrahim, Rania H. Mahmoud, Enas M. Hefzy, Omayma O Abdelaleem, Tarek I Ahmed, Essam A. Hassan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Science Population Single-nucleotide polymorphism Diseases medicine.disease_cause Biochemistry Microbiology Polymorphism Single Nucleotide Article Pathogenesis Medical research Hepatitis B Chronic Genotype Genetics Medicine SNP Humans Genetic Predisposition to Disease Risk factor education Hepatitis B virus education.field_of_study Multidisciplinary business.industry Hepatitis B mir-137 MicroRNAs Risk factors Immunology Egypt Female RNA Long Noncoding business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs, rs2067079 (C/T) and rs1625579 (G/T) were analyzed in 117 CHBV patients and 120 controls to investigate the probable association between these biomarkers and CHBV pathogenesis in the Egyptian population. Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. Regarding GAS5 (rs2067079), the mutant TT genotype showed an increased risk of CHBV (p p = 0.004). Regarding miR-137 rs1625579, the mutant genotype TT was reported as a risk factor for CHBV (p p = 0.007). Concerning miR-137 rs1625579, the mutant TT genotype was significantly associated with a lower serum expression level of miR-137 (p = 0.018). We revealed the dysregulated expression levels of GAS5 and miR-137 linked to their functioning SNPs were associated with CHBV risk and might act as potential therapeutic targets. |
| Databáze: | OpenAIRE |
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