Astrocytes have a license to kill inflammatory T cells
| Autor: | Alice H.K. Kwon, Shane A. Liddelow |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
T-Lymphocytes Immunology Degeneration (medical) Biology Mice 03 medical and health sciences 0302 clinical medicine Interferon medicine Animals Immunology and Allergy Inflammation LAMP1 Brain Spinal cord Killer Cells Natural Disease Models Animal 030104 developmental biology Infectious Diseases medicine.anatomical_structure Spinal Cord Astrocytes 030220 oncology & carcinogenesis Interferons Signal Transduction medicine.drug |
| Zdroj: | Immunity. 54:614-616 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2021.03.015 |
| Popis: | Summary Microbiome-induced interferon signaling through gut-derived natural killer cells is integral to minimize peripheral inflammatory responses in the brain and spinal cord. In a recent issue of Nature, Sanmarco, Wheeler, et al. define how interferon signaling induces LAMP1+TRAIL+ astrocytes, which cause death of inflammatory T cells, mitigating degeneration in a mouse model of demyealination. |
| Databáze: | OpenAIRE |
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