Prediction of kidney mercury content by isotope techniques
| Autor: | John B. Hursh, McKenna Ba, Ellen F. Miles, Thomas W. Clarkson, Pabico Rc, Thomas V. Nowak, Gibb Fr |
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| Jazyk: | angličtina |
| Předmět: |
MERCURE
medicine.medical_specialty Radioisotope Dilution Technique Time Factors chemistry.chemical_element Kidney Urinary excretion Dogs Female patient medicine Animals Humans Lung Gynecology Mercury Radioisotopes Chemistry Unithiol Mercury Middle Aged Inorganic mercury Mercury (element) Rats medicine.anatomical_structure Nephrology Mercury Poisoning Body Burden Female Industrial exposure |
| Zdroj: | Kidney International. (6):898-907 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1985.98 |
| Popis: | Prediction of kidney mercury content by isotope techniques. A 61-year-old female patient accidentally aspirated liquid mercury during a medically ordered diagnostic procedure. To develop animal-based guidelines, liquid mercury was introduced into the lungs of four dogs. Based on the study ofthese animals, a method of predicting the kidney inorganic mercury burden was developed using radioactive isotope dilution techniques. It was further demonstrated in dogs that oral administration of dimercaptopropane sulfonate (DMPS) increased mercury excretion and reduced the kidney burden. A rat experiment was performed permitting a statistical evaluation of the assumptions basic to the use of the method. The method was applied to the patient with the result that the kidney inorganic mercury burden was predicted to be 28.1mg, 8 months after the accident. Treatment with DMPS increased urinary excretion and the post-treatment kidney burden was estimated at 19.6mg Hg. Inasmuch as the radioactive dose to the subject may be kept at a negligible level and because sensitive methods exist for measurement of radioactive and stable mercury concentrations, the technique may be applicable in special cases to the estimation of kidney inorganic mercury burdens incurred by industrial exposure. Prediction du contenu renal en mercure par des techniques isotopiques. Une femme de 61 ans a aspire accidentellement du mercure liquide pendant un acte diagnostique prescrit par un medecin. Afin de developper des bases d'origine animale, du mercure liquide a ete introduit dans les poumons de quatre chiens. D'apres l'etude des ces animaux, une methode permettant de prevoir le contenu renal en mercure inorganique a ete developpee par des techniques de dilution d'isotope radioactif. Il a ensuite ete montre chez des chiens que l'administration orale de sulfonate de dimercaptopropane (DMPS) augmentait l'excretion mercurielle et en reduisait le contenu renal. Une experience a ete entreprise chez le rat pour permettre une evaluation statistique des hypotheses de base permettant l'emploi de la methode. Cette methode a ete appliquee a malade, et a permis de predire que le contenu renal en mercure inorganique etait de 28,1mg, 8 mois apres l'accident. Le traitement au DMPS a augmente l'excretion urinaire et le contenu renal post-therapeutique a ete estime a 19,6mg Hg. Dans la mesure ou la dose radioactive donnee au sujet peut etre maintenue a un niveau negligeable, et puisqu'il existe des methodes sensibles de mesure des concentrations de mercure radioactif et stable, cette technique est applicable a des cas particuliers pour estimer le contenu renal en mercure inorganique lie a une exposition industrielle. |
| Databáze: | OpenAIRE |
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