Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression
| Autor: | Ioachim, E., Charchanti, A., Briassoulis, E. Ch, Karavasilis, V., Tsanou, E., Arvanitis, D. L., Agnantis, Niki J., Pavlidis, Nicholas |
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| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961], Karavasilis, V. [0000-0002-5806-9399] |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
Pathology Collagen type 4 Antigens CD/metabolism Metastasis Cd Progesterone receptor Cohort Studies Tenascin/*metabolism Cancer growth Breast cancer Laminin Immunohistochemistry/methods 80 and over Estrogen receptor Fibronectins/*metabolism Priority journal Hermes antigen Aged 80 and over Collagen iv biology Cd44s Breast Neoplasms/*metabolism Scleroprotein Proteolytic enzymes Correlation analysis Tenascin Extracellular matrix Middle Aged Prognosis Immunohistochemistry Cancer size Extracellular Matrix Neoplasm Proteins Oncology Neoplasm proteins Disease Progression Lymph node Female Human Adult medicine.medical_specialty Stromal cell Breast carcinoma Cancer invasion Breast Neoplasms Major clinical study Cancer mortality Article Cancer grading Cathepsin Antigens CD medicine Neoplasm Proteins/*metabolism Humans Neoplasm Invasiveness Human tissue Antigens Fibronectin Aged Cancer medicine.disease Cathepsin d Survival Analysis Cancer survival Fibronectins Tumor progression Cancer research biology.protein Protein expression Laminin/*metabolism Ki 67 antigen Extracellular Matrix/*metabolism Breast neoplasms Controlled study |
| Zdroj: | European journal of cancer |
| Popis: | The immunohistochemical expression of the extracellular matrix (ECM) components tenascin (TN), fibronectin (FN), collagen type IV (Coll) and laminin (LN), and their possible relationships were studied in a series of 134 operable breast cancer cases. Their expression was also compared with the expression of the proteolytic enzyme cathepsin D (CD), the adhesion molecule CD44 standard form (CD44s) and other known factors to clarify the prognostic value and role of these molecules in tumour progression and metastasis. TN expression in the tumour stroma was positively correlated with tumour grade and size, CD44s expression, tumour and stromal CD expression as well as with FN, laminin and Coll expression in the same areas. TN expression was inverse correlated with ER status. Its expression at the invasion front was only positively correlated with the lymph node status. Survival analysis showed an increased mortality risk associated with high levels of TN expression. In multivariate analysis, among the ECM proteins, only TN expression was independently correlated with patients' survival. FN expression was positively correlated with lymph node involvement, with the proliferation-associated index Ki-67 and stromal CD expression. Survival analysis showed an increased mortality risk associated with a high level of FN expression. Coll expression was positively correlated with the tumour size and LN expression. An inverse relationship of Coll expression with ER and PgR receptor status was also found. LN expression was positively correlated with tumour and stromal CD expression, with the proliferation-associated index Ki-67 and inversely with ER receptor status. The observed alterations in the expression of ECM proteins in breast cancer tissue and their correlations with the proteolytic enzyme CD and the adhesion molecule CD44s, suggest an involvement in cancer progression. In addition, overexpression of stromal TN and FN seems to have negative prognostic value in breast cancer patients. © 2002 Elsevier Science Ltd. All rights reserved. 38 18 2362 2370 |
| Databáze: | OpenAIRE |
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