Serotonin Type 1D Receptors (5HT1DR) are Differentially Distributed in Nerve Fibres Innervating Craniofacial Tissues
| Autor: | Michael Gold, Andrea Harriott |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Calcitonin
medicine.medical_specialty Superior cervical ganglion Tyrosine 3-Monooxygenase Carotid Artery Common Migraine Disorders Blotting Western Neuropeptide Nerve Tissue Proteins Superior Cervical Ganglion Article Rats Sprague-Dawley Trigeminal ganglion Nerve Fibers Facial Pain Internal medicine medicine Animals Protein Precursors Receptor Afferent Pathways Tyrosine hydroxylase business.industry General Medicine Tryptamines Rats Serotonin Receptor Agonists Nociception Endocrinology Trigeminal Ganglion Organ Specificity Receptor Serotonin 5-HT1D Circle of Willis Immunohistochemistry Female Dura Mater Neurology (clinical) Serotonin business |
| Zdroj: | Cephalalgia. 28:933-944 |
| ISSN: | 1468-2982 0333-1024 |
| Popis: | We tested the hypothesis that the 5HT1DR, the primary antinociceptive target of triptans, is differentially distributed in tissues responsible for migraine pain. The density of 5HT1DR was quantified in tissues obtained from adult female rats with Western blot analysis. Receptor location was assessed with immunohistochemistry. The density of 5HT1DR was significantly greater in tissues known to produce migraine-like pain (i.e. circle of Willis and dura) than in structures in which triptans have no antinociceptive efficacy (i.e. temporalis muscle). 5HT1DR-like immunoreactivity was restricted to neuronal fibres, where it colocalized with calcitonin gene-related peptide and tyrosine hydroxylase immunoreactive fibres. These results are consistent with our hypothesis that the limited therapeutic profile of triptans could reflect its differential peripheral distribution and that the antinociceptive efficacy reflects inhibition of neuropeptide release from sensory afferents. An additional site of action at sympathetic efferents is also suggested. |
| Databáze: | OpenAIRE |
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