Does periodontitis affect the treatment response of biologics in the treatment of rheumatoid arthritis?
| Autor: | Hirotaka Chikuda, Tetsuya Kaneko, Takahito Suto, Chisa Okura, Trang Thuy Dam, Masahiro Tachibana, Yoshito Tsushima, Koichi Okamura, Tsuyoshi Tajika, Hideo Sakane, Yukio Yonemoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Standardized uptake value Treatment response Gastroenterology Arthritis Rheumatoid 03 medical and health sciences Biological Factors 0302 clinical medicine Internal medicine Positron Emission Tomography Computed Tomography Medicine Rheumatoid factor Humans Rheumatoid arthritis Periodontitis Pathological 030203 arthritis & rheumatology Biological Products medicine.diagnostic_test business.industry 030206 dentistry Middle Aged medicine.disease Rheumatology FDG-PET/CT medicine.anatomical_structure Erythrocyte sedimentation rate Female Ankle lcsh:RC925-935 business Research Article Biologic therapy |
| Zdroj: | Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-7 (2020) Arthritis Research & Therapy |
| ISSN: | 1478-6362 |
| DOI: | 10.1186/s13075-020-02269-x |
| Popis: | Background Rheumatoid arthritis (RA) and periodontitis (PD) have been suggested to share many clinical and pathological features. However, few reports have investigated the relationship between the degree of PD and the treatment response to RA. This study aimed to examine the relationship between the extent of PD and the treatment response to biologics in RA patients using FDG-PET/CT. Methods Sixty RA patients (male, n = 14; female, n = 46; average age, 58.3 years) treated with biologic agents were included in this study. FDG-PET/CT was performed at baseline and 6 months after the initiation of biological therapy. The maximum standardized uptake value (SUVmax) was used as a representative value for the assessment of the FDG uptake in periodontal tissue and joints including the bilateral shoulders, elbows, wrists, hip, knees, and ankle joints. The Disease Activity Score (DAS) 28-CRP and the following clinical parameters were assessed: C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide antibody (ACPA), rheumatoid factor (RF), and matrix metalloproteinase 3 (MMP-3). The relationship between the treatment response of RA and the baseline SUVmax of the periodontal tissue was evaluated. Results The baseline periodontal SUVmax was related to patient age (r = 0.302, p = 0.009) and the ACPA level (r = 0.265, p = 0.025). The DAS28-CRP, CRP, ESR, MMP-3, and joint SUVmax values were significantly decreased after 6 months of biological therapy. However, the mean periodontal SUVmax, ACPA, and RF showed no significant changes after treatment. There was a significantly negative correlation between the baseline periodontal SUVmax and the treatment response of DAS28-CRP (r = − 0.369, p = 0.004). Conclusion There was a negative correlation between the extent of PD at baseline and the treatment response of RA patients who received biological therapy. The evaluation of the periodontal condition is considered to be an essential part for the management of RA. |
| Databáze: | OpenAIRE |
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