Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model

Autor: Josep Lluís Torres, Eduardo García-Egido, Montserrat Giralt, Gabriel Dasilva, Isabel Medina, Jara Pérez-Jiménez, M. R. Nogués, Manuel Pazos
Přispěvatelé: Ministerio de Economía y Competitividad (España), Farmacobiologia Cel.lular, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
medicine.disease_cause
Analytical Chemistry
0302 clinical medicine
Ciències de la salut
Metabolic Syndrome
chemistry.chemical_classification
biology
General Medicine
Lipids
Ciencias de la salud
Eicosapentaenoic acid
DHA
Eicosapentaenoic Acid
METABOLISME
Docosahexaenoic acid
030220 oncology & carcinogenesis
lipids (amino acids
peptides
and proteins)
medicine.symptom
Polyunsaturated fatty acid
medicine.medical_specialty
Docosahexaenoic Acids
Lipid mediators
Inflammation
03 medical and health sciences
Internal medicine
Lipidomics
medicine
Animals
SHROB
0308-8146
Health sciences
EPA
medicine.disease
Rats
Disease Models
Animal
Metabolism
030104 developmental biology
Endocrinology
Fatty acid desaturase
chemistry
Oxidative stress
ÀCIDS GRASSOS
biology.protein
Metabolic syndrome
FATTY ACIDS
Biomarkers
Food Science
Zdroj: Food Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 0308-8146
DOI: 10.1016/j.foodchem.2016.03.020
Popis: 8 páginas, 4 tablas
The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS
This work was supported by the Spanish Ministerio de Economía y Competitividad (AGL2009-12374-C3-1, -2, and -3, and AGL2013-49079-C2-1,2-R). The Consejo Superior de Investigaciones Científicas (CSIC) and the University of Santiago de Compostela (USC) are gratefully acknowledged for the doctoral fellowship to Gabriel Dasilva. Xunta de Galicia and European Social Fund are also thankfully recognized for the financial support of the postdoctoral contracts to M. P and E.G.-E., and ISCIII for the postdoctoral contract “Sara Borrell” to J.P.-J. (CD09/00068)
Databáze: OpenAIRE
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