In vitro cytotoxic activity of Brazilian Middle West plant extracts
| Autor: | Hemerson Iury Ferreira Magalhães, Letícia Veras Costa Lotufo, Maria Rita Marques, Cláudia Pessoa, Talal Suleiman Mahmoud, Aristeu Gomes Tininis, José Eduardo Dutra de Oliveira, Manoel Odorico de Moraes, Dênis Pires de Lima |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade Federal de Mato Grosso do Sul (UFMS), Universidade Federal do Ceará (UFC), Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
food.ingredient
Pharmacognosy lcsh:RS1-441 Brazilian Middle-west plants lcsh:Pharmacy and materia medica food Botany Anacardiaceae Tapirira guianensis General Pharmacology Toxicology and Pharmaceutics Genes Neoplásicos Myracrodruon urundeuva cancer cell lines biology Traditional medicine Cytotoxins Eugenia uniflora Schinus terebinthifolius Farmacognosia biology.organism_classification Attalea phalerata Tabebuia Annonaceae Citotoxinas cytotoxicity Genes Neoplasm |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 21, Iss 3, Pp 456-464 (2011) Repositório Institucional da UFMS Universidade Federal de Mato Grosso do Sul (UFMS) instacron:UFMS Revista Brasileira de Farmacognosia, Volume: 21, Issue: 3, Pages: 456-464, Published: 15 APR 2011 Revista Brasileira de Farmacognosia v.21 n.3 2011 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 0102-695X |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:57:49Z No. of bitstreams: 1 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5) Made available in DSpace on 2013-08-22T18:57:49Z (GMT). No. of bitstreams: 1 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5) Previous issue date: 2011-06-01 Made available in DSpace on 2013-09-30T19:52:55Z (GMT). No. of bitstreams: 2 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5) S0102-695X2011000300017.pdf.txt: 34706 bytes, checksum: 4337f4bc24090c2d237bfc215fac6eee (MD5) Previous issue date: 2011-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:19:55Z No. of bitstreams: 2 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5) S0102-695X2011000300017.pdf.txt: 34706 bytes, checksum: 4337f4bc24090c2d237bfc215fac6eee (MD5) Made available in DSpace on 2014-05-20T14:19:55Z (GMT). No. of bitstreams: 2 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5) S0102-695X2011000300017.pdf.txt: 34706 bytes, checksum: 4337f4bc24090c2d237bfc215fac6eee (MD5) Previous issue date: 2011-06-01 Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT) Financiadora de Estudos e Projetos (FINEP) Cytotoxic activity of eight plant extracts, native from the Mid-West of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL-1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL-1) was used as the positive control and the MTT method was used to detect the activity. Cytotoxicity of distinct polarities was observed in thirty extracts (46%), from different parts of the following species: Tabebuia heptaphylla (Vell.) Toledo, Bignoniaceae, Tapirira guianensis Aubl., Anacardiaceae, Myracrodruon urundeuva Allemão, Anacardiaceae, Schinus terebinthifolius Raddi, Anacardiaceae, Gomphrena elegans Mart., Amaranthaceae, Attalea phalerata Mart. ex Spreng., Arecaceae, Eugenia uniflora L., Myrtaceae, and Annona dioica A. St.-Hil., Annonaceae. Extracts of at least two tested cell strains were considered to be highly active since their inhibition rate was over 75%. Universidade Estadual Paulista Instituto de Química Fundação Universidade Federal do Mato Grosso do Sul Laboratório de Bioquímica Vegetal Universidade Federal do Ceará (UFC) Laboratório de Oncologia Experimental Fundação Universidade Federal do Mato Grosso do Sul Departamento de Química Instituto Federal de Educação, Ciência e Tecnologia de São Paulo Campus de Sertãozinho Universidade Estadual Paulista Instituto de Química |
| Databáze: | OpenAIRE |
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