Efficacy of Repeated Intraperitoneal Administration of Levobupivacaine in Pain and Opioid Consumption After Elective Laparoscopic Cholecystectomy: A Prospective Randomized Placebo-controlled Trial
| Autor: | Aggeliki Pandazi, Artemisia Papadima, George C. Zografos, Eleni Melidi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Visual analogue scale medicine.drug_class Analgesic Placebo-controlled study 030230 surgery Placebo Fentanyl 03 medical and health sciences 0302 clinical medicine Shoulder Pain 030202 anesthesiology medicine Humans Prospective Studies Anesthetics Local Levobupivacaine Bupivacaine Pain Postoperative Local anesthetic business.industry Middle Aged Abdominal Pain Surgery Analgesics Opioid Treatment Outcome Cholecystectomy Laparoscopic Anesthesia Female business Injections Intraperitoneal medicine.drug |
| Zdroj: | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 26:295-300 |
| ISSN: | 1530-4515 |
| DOI: | 10.1097/sle.0000000000000297 |
| Popis: | PURPOSE To estimate the effect of intraperitoneal levobupivacaine on postoperative pain and analgesic requirements, during the first 24 hours after elective laparoscopic cholecystectomy (LC). MATERIALS AND METHODS In this prospective, randomized, placebo-controlled study, 73 consecutive patients scheduled for LC were randomized into 2 groups. In the local anesthetic group 36 patients received 10 mL of 0.5% levobupivacaine intraperitoneally at the end of the LC and at 4 hours postoperatively, whereas in the placebo group 37 patients received 10 mL of 0.9% normal saline. Visual analog scale pain scores, analgesic consumption, side-effects, and vital signs were recorded for 24 hours postoperatively. RESULTS In the local anesthetic group lower visual analog scale pain scores were observed postoperatively, both at rest and at movement (P-values compared with placebo, 0.012 and |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|