Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1
| Autor: | Malcolm Lim, Stephen B. Fox, Mark Bettington, Gavin Harris, David Papadimos, Lucinda D Taege, James Bennett, Emarene Kalaw, Sunil R. Lakhani, Puay Hoon Tan, Anna Sokolova, Kate J. Johnstone, Sandra A O'Toole, Gary Tse, Amy E. McCart Reed, Jamie R. Kutasovic, Peter T. Simpson, Rajadurai Pathmanathan, Nirmala Pathmanathan, Kaltin Ferguson, Jodi M. Saunus, Rin Yamaguchi, Colleen Niland, Irma Gresshoff |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Cancer Research chemical and pharmacologic phenomena Breast Neoplasms B7-H1 Antigen Article Tumour biomarkers 03 medical and health sciences 0302 clinical medicine Breast cancer Lymphocytes Tumor-Infiltrating PD-L1 Metaplasia medicine Biomarkers Tumor Humans Clinical significance Immune Checkpoint Inhibitors Aged biology Tumor-infiltrating lymphocytes business.industry FOXP3 hemic and immune systems Forkhead Transcription Factors Metaplastic Breast Carcinoma Middle Aged medicine.disease Immune checkpoint Oncology 030220 oncology & carcinogenesis biology.protein Cancer research Female medicine.symptom business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 |
| Popis: | Background Metaplastic breast carcinoma encompasses a heterogeneous group of tumours with differentiation into squamous and/or spindle, chondroid, osseous or rhabdoid mesenchymal-looking elements. Emerging immunotherapies targeting Programmed Death Ligand 1 (PD-L1) and immune-suppressing T cells (Tregs) may benefit metaplastic breast cancer patients, which are typically chemo-resistant and do not express hormone therapy targets. Methods We evaluated the immunohistochemical expression of PD-L1 and FOXP3, and the extent of tumour infiltrating lymphocytes (TILs) in a large cohort of metaplastic breast cancers, with survival data. Results Metaplastic breast cancers were significantly enriched for PD-L1 positive tumour cells, compared to triple-negative ductal breast cancers (P P = 0.0226). Multivariate analysis identified FOXP3 iTILs expression status as an important independent prognostic factor for patient survival. Conclusions Our findings indicate the clinical significance and prognostic value of FOXP3, PD-1/PD-L1 checkpoint and TILs in metaplastic breast cancer and confirm that a subset of metaplastics may benefit from immune-based therapies. |
| Databáze: | OpenAIRE |
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