(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities

Autor:	Roonglawan Rattanajak, Thunwadee Limtharakul, Stephen G. Pyne, Sumalee Kamchonwongpaisan, Thanika Promchai, Thanaphat Thaima
Rok vydání:	2019
Předmět:	Indole test 010405 organic chemistry Chemistry Organic Chemistry Plant Science 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Chemical constituents Organic chemistry Cytotoxic T cell Cytotoxicity Anomianthus dulcis
Zdroj:	Natural Product Research. 35:2476-2481
ISSN:	1478-6427 1478-6419
Popis:	A new farnesylindole, (R)-3-(8'-hydroxyfarnesyl)-indole (1), as a scalemic mixture (33% ee) along with nine known compounds (2-10), including one farnesylindole, three flavanones, three flavone derivatives and two chalcone derivatives were isolated from the methanolic crude extract of the flowers from Anomianthus dulcis. All compounds were purified by appropriate chromatographic techniques and their structures elucidated by spectroscopic methods. Compounds 1, 2 and 8 showed moderate antiplasmodial activities against TM4/8.Two and K1CB1 strains of which compound 2 displayed the best activity with IC50 values of 27.9 ± 2.57 and 21.4 ± 1.68 µM, respectively. In addition, compound 1 also presented modest cytotoxicity against a KB cell line with an IC50 value of 22.3 ± 0.39 µM. None of these compounds showed cytotoxicity against Vero cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f46cfc5c89bb0218db45f324531db6a https://doi.org/10.1080/14786419.2019.1679139 Zobrazit plný text záznamu