Ovariectomy increases the phenotypic plasticity of the female prostate epithelium in the Mongolian gerbil (Meriones unguiculatus)
| Autor: | Fernanda C. A. Santos, Sebastião Roberto Taboga, Marianna Zanatelli, Patricia S.L. Vilamaior, Luiz R. Falleiros, Rejane M. Góes, Manoel F. Biancardi, Ana M. G. Custodio |
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| Přispěvatelé: | Universidade Estadual de Campinas (UNICAMP), Universidade Federal de Goiás (UFG), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cell type Ovariectomy Population Reproductive technology Biology Gerbil Epithelium 03 medical and health sciences 0302 clinical medicine Endocrinology immunocytochemistry Microscopy Electron Transmission Prostate hormonal deprivation Internal medicine Genetics medicine Animals secretory cells education Molecular Biology education.field_of_study electron microscopy Genitalia Female 030104 developmental biology medicine.anatomical_structure Reproductive Medicine 030220 oncology & carcinogenesis Female Animal Science and Zoology Gerbillinae cell types Spermatogenesis Developmental Biology Biotechnology Hormone |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2018-12-11T17:14:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01 The female prostate is a reproductive gland that typically presents a morphology similar to that of the male gland and is highly developed in female Mongolian gerbils. Two main cell populations compose the epithelium gland: basal and secretory luminal cells. However, during postnatal development, diverse secretory cell phenotypes are distributed among the typical ones. Prostate homeostasis is under the control of sexual hormones, such as oestrogen and progesterone. After hormonal deprivation the female gland undergoes several morphophysiological changes. The objective of this study was to identify and characterise, structurally and ultrastructurally, the cellular heterogeneity of the female prostate epithelium in normal conditions and after ovariectomy. Histological routine stains, such as haematoxylin-eosin, periodic acid-Schiff and silver impregnation, as well as immunocytochemical techniques were used to enable identification of the different cell types. Some secretory cells types were identified and characterised as mucinous, basophil, clear, ciliated, droplet, spumous and neuroendocrine cells. Population tally data showed that the hormonal suppression caused by ovariectomy resulted in a decrease in the proportions of basophil and clear cells and an increase in spumous cells. Thus, the secretory epithelial cells of the female gerbil prostate are not morphologically and functionally uniform, presenting a phenotypical plasticity according to the hormonal environment in which they operate. Department of Structural and Functional Biology Institute of Biology State University of Campinas UNICAMP Department of Morphology Federal University of Goiás UFG Laboratory of Microscopy and Microanalysis Department of Biology São Paulo State University UNESP/IBILCE, R Cristovão Colombo, 2265 Laboratory of Microscopy and Microanalysis Department of Biology São Paulo State University UNESP/IBILCE, R Cristovão Colombo, 2265 |
| Databáze: | OpenAIRE |
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