Validation of PET/MRI attenuation correction methodology in the study of brain tumours
| Autor: | Lennart Blomqvist, Anna Falk Delgado, Francesca De Luca, Heather Martin, Martin Bolin, Cecilia Wassberg |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Frontal cortex Attenuation correction Intraclass correlation Tumour recurrence Neuroimaging Atlas-AC Correlation CT-AC symbols.namesake Atlases as Topic Methionine Magnetic resonance imaging Atlas (anatomy) Positron Emission Tomography Computed Tomography medicine Image Processing Computer-Assisted Humans Radiology Nuclear Medicine and imaging Carbon Radioisotopes Aged Retrospective Studies Physics medicine.diagnostic_test business.industry Brain Neoplasms Brain tumour Middle Aged Reference Standards Prognosis Pearson product-moment correlation coefficient ZTE–AC medicine.anatomical_structure PET/MRI Positron emission tomography symbols Female Nuclear medicine business Correction for attenuation Biomarkers Research Article |
| Zdroj: | BMC Medical Imaging |
| ISSN: | 1471-2342 |
| Popis: | Background This study aims to compare proton density weighted magnetic resonance imaging (MRI) zero echo time (ZTE) and head atlas attenuation correction (AC) to the reference standard computed tomography (CT) based AC for 11C-methionine positron emission tomography (PET)/MRI. Methods A retrospective cohort of 14 patients with suspected or confirmed brain tumour and 11C-Methionine PET/MRI was included in the study. For each scan, three AC maps were generated: ZTE–AC, atlas-AC and reference standard CT-AC. Maximum and mean standardised uptake values (SUV) were measured in the hotspot, mirror region and frontal cortex. In postoperative patients (n = 8), SUV values were additionally obtained adjacent to the metal implant and mirror region. Standardised uptake ratios (SUR) hotspot/mirror, hotspot/cortex and metal/mirror were then calculated and analysed with Bland–Altman, Pearson correlation and intraclass correlation reliability in the overall group and subgroups. Results ZTE–AC demonstrated narrower SD and 95% CI (Bland–Altman) than atlas-AC in the hotspot analysis for all groups (ZTE overall ≤ 2.84, − 1.41 to 1.70; metal ≤ 1.67, − 3.00 to 2.20; non-metal ≤ 3.04, − 0.96 to 3.38; Atlas overall ≤ 4.56, − 1.05 to 3.83; metal ≤ 3.87, − 3.81 to 4.64; non-metal ≤ 4.90, − 1.68 to 5.86). The mean bias for both ZTE–AC and atlas-AC was ≤ 2.4% compared to CT-AC. In the metal region analysis, ZTE–AC demonstrated a narrower mean bias range—closer to zero—and narrower SD and 95% CI (ZTE 0.21–0.48, ≤ 2.50, − 1.70 to 2.57; Atlas 0.56–1.54, ≤ 4.01, − 1.81 to 4.89). The mean bias for both ZTE–AC and atlas-AC was within 1.6%. A perfect correlation (Pearson correlation) was found for both ZTE–AC and atlas-AC compared to CT-AC in the hotspot and metal analysis (ZTE ρ 1.00, p 0.99). Conclusions Both ZTE and atlas-AC showed a good performance against CT-AC in patients with brain tumour. |
| Databáze: | OpenAIRE |
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