Potential roles of myoglobin autoxidation in myocardial ischemia-reperfusion injury
| Autor: | Michael R. Gunther, Vijaya Sampath, Winslow S. Caughey |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
inorganic chemicals
medicine.medical_specialty Hot Temperature Ischemia chemistry.chemical_element Myocardial Reperfusion Injury Buffers medicine.disease_cause Biochemistry Oxygen chemistry.chemical_compound Superoxides Physiology (medical) Internal medicine medicine Animals Hydrogen peroxide Autoxidation Myoglobin Superoxide Hydrogen-Ion Concentration medicine.disease Kinetics Endocrinology chemistry Metals Cattle Oxidation-Reduction Reperfusion injury Oxidative stress |
| Zdroj: | Free Radical Biology and Medicine. 26:1388-1395 |
| ISSN: | 0891-5849 |
| Popis: | The source(s) of reactive partially reduced oxygen species associated with myocardial ischemia/reperfusion injury remain unclear and controversial. Myoglobin has not been viewed as a participant but is present in relatively high concentrations in heart muscle and, even under normal conditions, undergoes reactions that generate met (Fe3+) species and also superoxide, hydrogen peroxide, and other oxidants, albeit slowly. The degree to which the decrease in pH and the freeing of copper ions, as well as the variations in pO2 associated with ischemia and reperfusion increase the rates of such myoglobin reactions has been investigated. Solutions of extensively purified myoglobin from bovine heart in 50 mM sodium phosphate buffer were examined at 37 degrees C. Sufficiently marked rate increases were observed to indicate that reactions of myoglobin can indeed contribute substantially to the oxidant stress associated with ischemia/reperfusion injury in myocardial tissues. These findings provide additional targets for therapeutic interventions. |
| Databáze: | OpenAIRE |
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