A Kinematic Study of Progressive Micrographia in Parkinson's Disease
| Autor: | Poonam Zham, Sanjay Raghav, Peter Kempster, Sridhar Poosapadi Arjunan, Kit Wong, Kanae J. Nagao, Dinesh K. Kumar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease kinematic Kinematics Motor function lcsh:RC346-429 050105 experimental psychology Part iii 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation progressive micrographia Medicine Offline analysis 0501 psychology and cognitive sciences Stroke lcsh:Neurology. Diseases of the nervous system Original Research business.industry 05 social sciences medicine.disease Control subjects Micrographia Neurology bradykinesia Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery handwriting |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 10 (2019) |
| ISSN: | 1664-2295 |
| Popis: | Progressive micrographia is decrement in character size during writing and is commonly associated with Parkinson’s disease (PD). This study has investigated the kinematic features of progressive micrographia during a repetitive writing task. Twenty-four PD patients with duration since diagnosis of less than 10 years and 24 age-matched controls wrote the letter ‘e’ repeatedly. PD patients were studied in defined off states, with scoring of motor function on the Unified Parkinson’s Disease Rating Scale Part III. A digital tablet captured x-y coordinates and ink-pen pressure. Customized software recorded the data and offline analysis derived the kinematic features of pen-tip movement. The average size of the first and the last five letters were compared, with progressive micrographia defined as greater than 10% decrement in letter stroke length. The relationships between dimensional and kinematic features for the control subjects and for PD patients with and without progressive micrographia were studied. Differences between the initial and last letter repetitions within each group were assessed by Wilcoxon signed-rank test, and the Kruskal-Wallis test was applied to compare the three groups. There are five main conclusions from our findings: (i) 66% of PD patients who participated in this study exhibited progressive micrographia; (ii) handwriting kinematic features for all PD patients was significantly lower than controls (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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