Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment
| Autor: | Robert C. Hickner, Justin D. La Favor, Jillian T. Dawkins, Ethan J. Anderson, Christopher J. Wingard |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Sepiapterin Time Factors Physiology Vasodilator Agents Vasodilation Coronary Artery Disease Diet High-Fat Rats Sprague-Dawley Coronary artery disease chemistry.chemical_compound Erectile Dysfunction Physiology (medical) Internal medicine medicine Animals Aerobic exercise Obesity Enzyme Inhibitors Endothelial dysfunction Dose-Response Relationship Drug business.industry Penile Erection Acetophenones NADPH Oxidases medicine.disease Biopterin Coronary Vessels Electric Stimulation Exercise Therapy Pterins Rats Obesity Diabetes and Energy Homeostasis Disease Models Animal Oxidative Stress Endocrinology Erectile dysfunction chemistry Apocynin Cardiology Endothelium Vascular Sedentary Behavior business |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 305:R423-R434 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.00049.2013 |
| Popis: | The aim of this study was to investigate aerobic exercise training as a means to prevent erectile dysfunction (ED) and coronary artery disease (CAD) development associated with inactivity and diet-induced obesity. Male Sprague-Dawley rats were fed a Western diet (WD) or a control diet (CD) for 12 wk. Subgroups within each diet remained sedentary (Sed) or participated in aerobic interval treadmill running throughout the dietary intervention. Erectile function was evaluated under anesthesia by measuring the mean arterial pressure and intracavernosal pressure in response to electrical field stimulation of the cavernosal nerve, in the absence or presence of either apocynin, an NADPH oxidase inhibitor, or sepiapterin, a tetrahydrobiopterin precursor. Coronary artery endothelial function (CAEF) was evaluated ex vivo with cumulative doses of ACh applied to preconstricted segments of the left anterior descending coronary artery. CAEF was assessed in the absence or presence of apocynin or sepiapterin. Erectile function ( P < 0.0001) and CAEF ( P < 0.001) were attenuated in WD-Sed. Exercise preserved erectile function ( P < 0.0001) and CAEF ( P < 0.05) within the WD. Erectile function ( P < 0.01) and CAEF ( P < 0.05) were augmented by apocynin only in WD-Sed, while sepiapterin ( P < 0.05) only augmented erectile function in WD-Sed. These data demonstrate that a chronic WD induces impairment in erectile function and CAEF that are commonly partially reversible by apocynin, whereas sepiapterin treatment exerted differential functional effects between the two vascular beds. Furthermore, exercise training may be a practical means of preventing diet-induced ED and CAD development. |
| Databáze: | OpenAIRE |
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